A selective sorbent for removing bacterial endotoxins from blood

A. S. Morozov; M. N. Kopitsyna; I. V. Bessonov; N. V. Karelina; A. V. Nuzhdina; I. Yu. Sarkisov; L. A. Pavlova; M. P. Tsyurupa; Z. K. Blinnikova; V. A. Davankov

doi:10.1134/S0036024416120165

A selective sorbent for removing bacterial endotoxins from blood

Autores: Morozov A.¹, Kopitsyna M.¹, Bessonov I.¹, Karelina N.¹, Nuzhdina A.¹, Sarkisov I.², Pavlova L.³, Tsyurupa M.³, Blinnikova Z.³, Davankov V.³
Afiliações:
1. Bauman State Technical University
2. NPP Biotekh-M OOO
3. Nesmeyanov Institute of Organoelement Compounds
Edição: Volume 90, Nº 12 (2016)
Páginas: 2465-2470
Seção: Physical Chemistry of Surface Phenomena
URL: https://journals.rcsi.science/0036-0244/article/view/169069
DOI: https://doi.org/10.1134/S0036024416120165
ID: 169069

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Resumo

Synthetic ligands carrying a positive charge and capable of selective binding of bacterial endotoxins are covalently immobilized on surfaces of domestic hemosorbent Styrosorb-514 based on hypercrosslinked polystyrene. It is shown that the resulting sorbent aimed at treating sepsis exceeds imported specific hemosorbent in Toraymyxin™ columns in removing lipopolysaccharides, and can be used in domestically-produced Desepta columns.