Formation and Properties of Multilayer Films Based on Polyethyleneimine and Bovine Serum Albumin

Abstract

(Polyethyleneimine/bovine serum albumin)_n ((PEI/BSA)n) multilayer films (n = 1–10) are produced via the layer-by-later deposition of polyelectrolytes. It is shown that thickness and morphology of the formed coatings can be controlled by varying the solution’s ionic strength during alternating adsorption of the components. (PEI/BSA)₁₀ multilayer systems that contain up to 0.6 mg of antiseptic miramistin per 1 cm² of film were created. It is established that the kinetics of miramistin release from (PEI/BSA)₁₀ films in phosphate buffers and physiological solutions obey the Korsmeyer–Peppas equation with a high degree of accuracy (R₂ > 0.95).