Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile
- Authors: Stanojević A.1, Marković V.M.1, Čupić Ž.2, Vukojević V.3, Kolar-Anić L.1,2
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Affiliations:
- Faculty of Physical Chemistry
- Institute of Chemistry, Technology and Metallurgy, Department of Catalysis and Chemical Engineering
- Karolinska Institutet, Department of Clinical Neuroscience
- Issue: Vol 91, No 13 (2017)
- Pages: 2600-2607
- Section: Structure of Matter and Quantum Chemistry
- URL: https://journals.rcsi.science/0036-0244/article/view/169834
- DOI: https://doi.org/10.1134/S0036024417130027
- ID: 169834
Cite item
Abstract
A model was developed that can be used to study the effect of gradual cholesterol intake by food on the HPA axis dynamics. Namely, well defined oscillatory dynamics of vital neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis has proven to be necessary for maintaining regular basal physiology and formulating appropriate stress response to various types of perturbations. Cholesterol, as a precursor of all steroid HPA axis hormones, can alter the dynamics of HPA axis. To analyse its particular influence on the HPA axis dynamics we used stoichiometric model of HPA axis activity, and simulate cholesterol perturbations in the form of finite duration pulses, with asymmetrically distributed concentration profile. Our numerical simulations showed that there is a complex, nonlinear dependence between the HPA axis responsiveness and different forms of applied cholesterol concentration pulses, indicating the significance of kinetic modelling, and dynamical systems theory for the understanding of large-scale self-regulatory, and homeostatic processes within this neuroendocrine system.
About the authors
A. Stanojević
Faculty of Physical Chemistry
Author for correspondence.
Email: ana.stanojevic@ffh.bg.ac.rs
Serbia, Belgrade, 11158
V. M. Marković
Faculty of Physical Chemistry
Email: ana.stanojevic@ffh.bg.ac.rs
Serbia, Belgrade, 11158
Ž. Čupić
Institute of Chemistry, Technology and Metallurgy, Department of Catalysis and Chemical Engineering
Email: ana.stanojevic@ffh.bg.ac.rs
Serbia, Belgrade, 11000
V. Vukojević
Karolinska Institutet, Department of Clinical Neuroscience
Email: ana.stanojevic@ffh.bg.ac.rs
Sweden, Stockholm, 17176
L. Kolar-Anić
Faculty of Physical Chemistry; Institute of Chemistry, Technology and Metallurgy, Department of Catalysis and Chemical Engineering
Email: ana.stanojevic@ffh.bg.ac.rs
Serbia, Belgrade, 11158; Belgrade, 11000