Effect of additives on eremomycin sorbent selectivity in separation of salbutamol enantiomers using supercritical fluid chromatography
- Authors: Pokrovskiy O.I.1,2, Kayda A.S.2, Usovich O.I.2, Parenago O.O.1,2, Lunin V.V.1,2
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Affiliations:
- Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences
- Chemical Department
- Issue: Vol 91, No 11 (2017)
- Pages: 2288-2290
- Section: Short Communications
- URL: https://journals.rcsi.science/0036-0244/article/view/169786
- DOI: https://doi.org/10.1134/S0036024417140011
- ID: 169786
Cite item
Abstract
A regime is found in which chiral stationary phase based on macrocyclic glycopeptide eremomycin allows separation of salbutamol sulfate enantiomers in supercritical fluid chromatography. Enantioseparation occurs only when two dynamic modifiers are used simultaneously: isopropylamin + trifluoroacetic acid or isopropylamin + ammonium acetate. Amine molar concentration in mobile phase has to be higher than acid molar concentration, otherwise enantiomers coelute. We suppose that with amine excess a mechanism of enantiorecognition is realized which involves ionic sorbent-sorbate interactions. Such mechanism is well-known for glycopeptide chiral selectors in liquid chromatography, but for supercritical fluid chromatography it is reported for the first time.
About the authors
O. I. Pokrovskiy
Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences; Chemical Department
Author for correspondence.
Email: oleg.pokrovskiy@supercritical.ru
Russian Federation, Moscow; Moscow
A. S. Kayda
Chemical Department
Email: oleg.pokrovskiy@supercritical.ru
Russian Federation, Moscow
O. I. Usovich
Chemical Department
Email: oleg.pokrovskiy@supercritical.ru
Russian Federation, Moscow
O. O. Parenago
Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences; Chemical Department
Email: oleg.pokrovskiy@supercritical.ru
Russian Federation, Moscow; Moscow
V. V. Lunin
Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences; Chemical Department
Email: oleg.pokrovskiy@supercritical.ru
Russian Federation, Moscow; Moscow