Email this article Thermodynamic parameters analysis of ethidium bromide and mitoxantrone binding with DNA by adsorption isotherms
- Authors: Vardevanyan P.O.1, Parsadanyan M.A.1, Antonyan A.P.1, Hakobyan S.N.2
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Affiliations:
- Yerevan State University, Faculty of Biology
- State Engineering University of Armenia
- Issue: Vol 91, No 6 (2017)
- Pages: 1143-1145
- Section: Short Communications
- URL: https://journals.rcsi.science/0036-0244/article/view/169562
- DOI: https://doi.org/10.1134/S0036024417060280
- ID: 169562
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Abstract
Analysis of the adsorption isotherms by virtue of experimentally obtained data of anti-tumorous compound mitoxantrone and ethidium bromide binding with DNA has been carried out. The obtained data showed that throughout the comparatively simple linear isotherm, the more precise values of the binding constant K and number of nucleotides n, per binding site were received. Based on the values of K, those for the enthalpy changes at complex-formation of these ligands with DNA were obtained.
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About the authors
P. O. Vardevanyan
Yerevan State University, Faculty of Biology
Author for correspondence.
Email: p.vardevanyan@ysu.am
Armenia, Yerevan
M. A. Parsadanyan
Yerevan State University, Faculty of Biology
Email: p.vardevanyan@ysu.am
Armenia, Yerevan
A. P. Antonyan
Yerevan State University, Faculty of Biology
Email: p.vardevanyan@ysu.am
Armenia, Yerevan
S. N. Hakobyan
State Engineering University of Armenia
Email: p.vardevanyan@ysu.am
Armenia, Yerevan
