Thermodynamics of sulfamethoxazole dissolution in organic solvents at 293.15–323.15 K


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Abstract

The solubilities of the sulfonamide—sulfamethoxazole in methanol, ethanol, 1-propanol, 2-propanol, and chloroform have been determined at 293.15–323.15 K by a static equilibrium method. The experimental results can be approximated with Apelblat equation. The positive enthalpy ΔsolH and entropy ΔsolS for each system revealed that sulfamethoxazole dissolution in each solvent is an entropy-driven process.

About the authors

C.-L. Zhang

College of Chemical Engineering and Energy

Author for correspondence.
Email: zhangcl201@zzu.edu.cn
China, Zhengzhou, 450001

S.-J. Cui

College of Chemical Engineering and Energy

Email: zhangcl201@zzu.edu.cn
China, Zhengzhou, 450001


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