Comparing kinetic curves in liquid chromatography
- 作者: Kurganov A.A.1, Kanat’eva A.Y.1, Yakubenko E.E.1, Popova T.P.1, Shiryaeva V.E.1
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隶属关系:
- Topchiev Institute of Petrochemical Synthesis
- 期: 卷 91, 编号 1 (2017)
- 页面: 182-188
- 栏目: Physical Chemistry of Separation Processes. Chromatography
- URL: https://journals.rcsi.science/0036-0244/article/view/169207
- DOI: https://doi.org/10.1134/S0036024417010149
- ID: 169207
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详细
Five equations for kinetic curves which connect the number of theoretical plates N and time of analysis t0 for five different versions of optimization, depending on the parameters being varied (e.g., mobile phase flow rate, pressure drop, sorbent grain size), are obtained by means of mathematical modeling. It is found that a method based on the optimization of a sorbent grain size at fixed pressure is most suitable for the optimization of rapid separations. It is noted that the advantages of the method are limited by an area of relatively low efficiency, and the advantage of optimization is transferred to a method based on the optimization of both the sorbent grain size and the drop in pressure across a column in the area of high efficiency.
作者简介
A. Kurganov
Topchiev Institute of Petrochemical Synthesis
编辑信件的主要联系方式.
Email: kurganov@ips.ac.ru
俄罗斯联邦, Moscow, 119991
A. Kanat’eva
Topchiev Institute of Petrochemical Synthesis
Email: kurganov@ips.ac.ru
俄罗斯联邦, Moscow, 119991
E. Yakubenko
Topchiev Institute of Petrochemical Synthesis
Email: kurganov@ips.ac.ru
俄罗斯联邦, Moscow, 119991
T. Popova
Topchiev Institute of Petrochemical Synthesis
Email: kurganov@ips.ac.ru
俄罗斯联邦, Moscow, 119991
V. Shiryaeva
Topchiev Institute of Petrochemical Synthesis
Email: kurganov@ips.ac.ru
俄罗斯联邦, Moscow, 119991
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