Selective cytotoxic Pt(II) complexes of phenanthroline derivatives
- Авторлар: Abedi A.1
-
Мекемелер:
- Department of Chemistry, North Tehran Branch
- Шығарылым: Том 62, № 12 (2017)
- Беттер: 1595-1599
- Бөлім: Coordination Compounds
- URL: https://journals.rcsi.science/0036-0236/article/view/168224
- DOI: https://doi.org/10.1134/S0036023617120026
- ID: 168224
Дәйексөз келтіру
Аннотация
A new dichloroplatinum(II) complex with 5-methyl-1,10-phenanthroline (1) has been obtained and characterized by X-ray diffraction. MTT assay was used for in vitro cytotoxicity evaluation of this complex, along with a similar complex with 4,7-diphenyl-1,10-phenanthroline (2) against normal and cancerous cell lines. Interestingly, the IC50 values of the new complexes were higher for normal cells and in the case of complex 2, lower against all studied human cancer cells, in comparison with cisplatin.
Авторлар туралы
Anita Abedi
Department of Chemistry, North Tehran Branch
Хат алмасуға жауапты Автор.
Email: a_abedi@iau-tnb.ac.ir
Иран, Tehran, 19585-936
Қосымша файлдар
