Synthesis of Substituted Derivatives of  closo -Decaborate Anion with a Peptide Bond: The Way towards Designing Biologically Active Boron-Containing Compounds

A. V. Nelyubin; I. N. Klyukin; A. P. Zhdanov; M. S. Grigor’ev; K. Yu. Zhizhin; N. T. Kuznetsov

doi:10.1134/S003602361912012X

Synthesis of Substituted Derivatives of closo-Decaborate Anion with a Peptide Bond: The Way towards Designing Biologically Active Boron-Containing Compounds

Authors: Nelyubin A.V.¹, Klyukin I.N.¹, Zhdanov A.P.¹, Grigor’ev M.S.², Zhizhin K.Y.¹, Kuznetsov N.T.¹
Affiliations:
1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
2. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Issue: Vol 64, No 12 (2019)
Pages: 1499-1506
Section: Synthesis and Properties of Inorganic Compounds
URL: https://journals.rcsi.science/0036-0236/article/view/169583
DOI: https://doi.org/10.1134/S003602361912012X
ID: 169583

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Abstract

A novel scheme of multi-step synthesis for N-borylated dipeptide R-GlyPheOEt is proposed, which is based on the nucleophilic addition of amino acid derivatives to the [2-B₁₀H₉NCCH₃]^– anion. The products obtained at each step were studied by NMR, IR spectroscopy, and ESI mass spectrometry. The single-crystal structure of (NBu₄)[2-B₁₀H₉NH=C(NH₂CH₂COO^tC₄H₉)CH₃] was identified by XRD.