Experimental Modeling of Formation of the Basic Mineral Phases of Calcifications


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Abstract

Calcium phosphate phase formation was studied under process conditions involving human blood plasma. Calcium phosphate was synthesized with variable supersaturation (S) and experimental time. It was found that a non-stoichiometric hydrated carbonated hydroxyapatite, identical in the composition to calcifications in humans, is formed under the experimental conditions. The highest amount of carbonate ions (5.54 wt %) in the solid phase corresponds to the apatite synthesized at S = 50 for 10 weeks. The dissolution rate of solid phases was determined by mathematical processing of the obtained kinetic curves; this can be used to find compounds able to stop the development of vascular calcinosis.

About the authors

O. A. Golovanova

Dostoevsky Omsk State University

Author for correspondence.
Email: golovanoa2000@mail.ru
Russian Federation, Omsk, 644077

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