The influence of the sizes of nanodiamond aggregates in their suspensions on the efficiency of sorption of 90Y and 177Lu isotopes for their subsequent use in nuclear medicine
- Autores: Kazakov A.1, Babenya J.1, Ekatova T.1, Vinokurov S.1, Khvorostinin E.1, Ushakov I.2, Zukau V.2, Stasyuk E.2, Nesterov E.2, Sadkin V.2, Rogov A.2, Myasoedov B.1,3
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Afiliações:
- Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
- National Research Tomsk Polytechnic University
- Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences
- Edição: Volume 66, Nº 2 (2024)
- Páginas: 178–184
- Seção: Articles
- URL: https://journals.rcsi.science/0033-8311/article/view/263863
- DOI: https://doi.org/10.31857/S0033831124020093
- ID: 263863
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Resumo
Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for use in nuclear medicine. In this work, we investigated the influence of the properties of ND suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes 90Y and 177Lu and found the conditions for obtaining promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the ND surface, while the forms of cations of the studied nuclides in the solution do not affect the degree of sorption.
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Sobre autores
A. Kazakov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Autor responsável pela correspondência
Email: adeptak92@mail.ru
Rússia, Moscow
J. Babenya
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Rússia, Moscow
T. Ekatova
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Rússia, Moscow
S. Vinokurov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Rússia, Moscow
E. Khvorostinin
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Rússia, Moscow
I. Ushakov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Rússia, Tomsk
V. Zukau
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Rússia, Tomsk
E. Stasyuk
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Rússia, Tomsk
E. Nesterov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Rússia, Tomsk
V. Sadkin
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Rússia, Tomsk
A. Rogov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Rússia, Tomsk
B. Myasoedov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences
Email: adeptak92@mail.ru
Rússia, Moscow; Moscow
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