Hair follicle regeneration in vitro
- Authors: Kalabusheva E.P.1, Vorotelyak E.A.1
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Affiliations:
- Koltsov Institute of Developmental Biology
- Issue: Vol 50, No 14 (2016)
- Pages: 1656-1664
- Section: Article
- URL: https://journals.rcsi.science/0031-0301/article/view/166216
- DOI: https://doi.org/10.1134/S0031030116140045
- ID: 166216
Cite item
Abstract
Hair follicles (HF) are skin appendages that develop as a result of the epithelial-mesenchymal interactions. The HF mesenchymal component—dermal papilla (DP)—has an ability to induce HF growth after transplantation in afollicular epidermis; this ability is retained through several passages in culture. In the present study, early regeneration events of a human HF are designed in vitro, using DP cells and skin kerati-nocytes. An artificial hair germ model is developed to study the primary steps of the stem cell self-organiza-tion during HF regeneration.
Keywords
About the authors
E. P. Kalabusheva
Koltsov Institute of Developmental Biology
Author for correspondence.
Email: Kalabusheva.e@gmail.com
Russian Federation, ul. Vavilova 26, Moscow, 119334
E. A. Vorotelyak
Koltsov Institute of Developmental Biology
Email: Kalabusheva.e@gmail.com
Russian Federation, ul. Vavilova 26, Moscow, 119334