Email this article Advanced Nanotools for Imaging of Solid Tumors and Circulating and Disseminated Cancer Cells
- Authors: Ramos-Gomes F.1, Alves F.1,2, Chames P.3, Baty D.3, Nabiev I.4,5, Sukhanova A.4,5
-
Affiliations:
- Translational Molecular Imaging Unit, Max Planck Institute for Experimental Medicine
- Clinic of Haematology and Medical Oncology, University Medical Center Göttingen
- Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche Contre le Cancer de Marseille (CRCM)
- Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
- Laboratoire de Recherche en Nanosciences, LRN-EA4682, Ulniversité de Reims Champagne-Ardenne
- Issue: Vol 125, No 5 (2018)
- Pages: 703-707
- Section: Nanophotonics
- URL: https://journals.rcsi.science/0030-400X/article/view/165846
- DOI: https://doi.org/10.1134/S0030400X18110309
- ID: 165846
Cite item
Open Access
Access granted
Subscription Access
Abstract
Semiconductor quantum dots (QDs) are characterized by orders of magnitude higher multiphoton linear absorption cross-sections compared with conventional organic dyes. Combined with the QD photoluminescence quantum yield approaching 100% and their rock-solid photostability, this fact opens great prospects for the two-photon functional tumor imaging with QDs tagged with highly specific recognition molecules. Single-domain antibodies (sdAbs) or “nanobodies” derived from lamas are the smallest high-affinity recognition molecules, which may be tagged with the QDs thus permitting not only solid tumors multiphoton imaging but also rare disseminated cancer cells and micrometastases in the depth of the tissue to be detected.
About the authors
F. Ramos-Gomes
Translational Molecular Imaging Unit, Max Planck Institute for Experimental Medicine
Email: igor.nabiev@univ-reims.fr
Germany, Göttingen, 37075
F. Alves
Translational Molecular Imaging Unit, Max Planck Institute for Experimental Medicine; Clinic of Haematology and Medical Oncology, University Medical Center Göttingen
Email: igor.nabiev@univ-reims.fr
Germany, Göttingen, 37075; Göttingen, 37075
P. Chames
Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes,Centre de Recherche Contre le Cancer de Marseille (CRCM)
Email: igor.nabiev@univ-reims.fr
France, Marseille, 13009
D. Baty
Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes,Centre de Recherche Contre le Cancer de Marseille (CRCM)
Email: igor.nabiev@univ-reims.fr
France, Marseille, 13009
I. Nabiev
Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI(Moscow Engineering Physics Institute); Laboratoire de Recherche en Nanosciences, LRN-EA4682, Ulniversité de Reims Champagne-Ardenne
Author for correspondence.
Email: igor.nabiev@univ-reims.fr
Russian Federation, Moscow, 115409; Reims, 51100
A. Sukhanova
Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI(Moscow Engineering Physics Institute); Laboratoire de Recherche en Nanosciences, LRN-EA4682, Ulniversité de Reims Champagne-Ardenne
Email: igor.nabiev@univ-reims.fr
Russian Federation, Moscow, 115409; Reims, 51100
Supplementary files
