Synthesis and Antimicrobial Activity of N-(Indolyl)trifluoroacetamides

Resumo

A method for the synthesis of the corresponding trifluoroacetamides based on 2,3-dimethyl-, 1,2,3-trimethyl-7-aminoindoles and ethyl ester of trifluoroacetic acid is developed. The compounds obtained are screened for antimicrobial activity using the standard strains of the Staphylococcus aureus 29213, Escherichia coli 25922, Pseudomonas aeruginosa 27853, Streptococcus pyogenes 1238, and Klebsiella pneumonia 9172; and the antimicrobial activity comparable to dioksidin, a widely used antimicrobial drug, is demonstrated.