Email this article Synthesis and Antimicrobial Activity of N-(Indolyl)trifluoroacetamides
- Authors: Stepanenko I.S.1, Yamashkin S.A.2, Kot’kin A.I.2, Yurovskaya M.A.3
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Affiliations:
- Ogarev Mordovia State University
- Evseviev Mordovian State Pedagogical Institute
- Department of Organic Chemistry, Moscow State University
- Issue: Vol 74, No 5 (2019)
- Pages: 236-240
- Section: Article
- URL: https://journals.rcsi.science/0027-1314/article/view/164002
- DOI: https://doi.org/10.3103/S0027131419050109
- ID: 164002
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Abstract
A method for the synthesis of the corresponding trifluoroacetamides based on 2,3-dimethyl-, 1,2,3-trimethyl-7-aminoindoles and ethyl ester of trifluoroacetic acid is developed. The compounds obtained are screened for antimicrobial activity using the standard strains of the Staphylococcus aureus 29213, Escherichia coli 25922, Pseudomonas aeruginosa 27853, Streptococcus pyogenes 1238, and Klebsiella pneumonia 9172; and the antimicrobial activity comparable to dioksidin, a widely used antimicrobial drug, is demonstrated.
About the authors
I. S. Stepanenko
Ogarev Mordovia State University
Email: yamashk@yandex.ru
Russian Federation, Saransk
S. A. Yamashkin
Evseviev Mordovian State Pedagogical Institute
Author for correspondence.
Email: yamashk@yandex.ru
Russian Federation, Saransk
A. I. Kot’kin
Evseviev Mordovian State Pedagogical Institute
Email: yamashk@yandex.ru
Russian Federation, Saransk
M. A. Yurovskaya
Department of Organic Chemistry, Moscow State University
Email: yamashk@yandex.ru
Russian Federation, Moscow
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