Determination of Codeine Phosphate in the Culture Fluid of  Rhodococcus  by High-Performance Liquid Chromatography

A. N. Plotnikov; Yu. N. Karpenko; E. V. Vikhareva; E. A. Tyumina; M. I. Richkova; A. A. Selyaninov

doi:10.3103/S0027131418010054

Determination of Codeine Phosphate in the Culture Fluid of Rhodococcus by High-Performance Liquid Chromatography

Authors: Plotnikov A.N.¹, Karpenko Y.N.¹, Vikhareva E.V.¹, Tyumina E.A.², Richkova M.I.³, Selyaninov A.A.⁴
Affiliations:
1. Perm State Pharmaceutical Academy
2. Perm State National Research University
3. Institute of Ecology and Genetics of Microorganisms, Ural Branch
4. Perm National Research Polytechnic University
Issue: Vol 72, No 6 (2017)
Pages: 328-332
Section: Article
URL: https://journals.rcsi.science/0027-1314/article/view/163572
DOI: https://doi.org/10.3103/S0027131418010054
ID: 163572

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Abstract

The conditions for the quantitative determination of codeine phosphate in the culture fluid of Rhodococcus by reversed-phase high-performance liquid chromatography (RP-HPLC) are established. The specificity, linearity, precision, and accuracy of the method are confirmed by the validation procedure.