HIV Restriction Factors and Their Ambiguous Role during Infection
- Авторлар: Zotova A.A.1,2, Atemasova A.A.1, Filatov A.V.3, Mazurov D.V.2,3
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Мекемелер:
- Moscow State University, Faculty of Biology
- Cell and Gene Technology Group, Institute of Gene Biology, Russian Academy of Sciences
- National Research Center—Institute of Immunology of Federal Medical-Biological Agency of Russia
- Шығарылым: Том 53, № 2 (2019)
- Беттер: 212-226
- Бөлім: Reviews
- URL: https://journals.rcsi.science/0026-8933/article/view/163862
- DOI: https://doi.org/10.1134/S0026893319020171
- ID: 163862
Дәйексөз келтіру
Аннотация
Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.
Негізгі сөздер
Авторлар туралы
A. Zotova
Moscow State University, Faculty of Biology; Cell and Gene Technology Group, Institute of Gene Biology, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: ashunaeva@gmail.com
Ресей, Moscow, 119991; Moscow, 119334
A. Atemasova
Moscow State University, Faculty of Biology
Email: ashunaeva@gmail.com
Ресей, Moscow, 119991
A. Filatov
National Research Center—Institute of Immunology of Federal Medical-Biological Agency of Russia
Email: ashunaeva@gmail.com
Ресей, Moscow, 115478
D. Mazurov
Cell and Gene Technology Group, Institute of Gene Biology, Russian Academy of Sciences; National Research Center—Institute of Immunology of Federal Medical-Biological Agency of Russia
Email: ashunaeva@gmail.com
Ресей, Moscow, 119334; Moscow, 115478
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