HIV Restriction Factors and Their Ambiguous Role during Infection


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Аннотация

Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.

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Авторлар туралы

A. Zotova

Moscow State University, Faculty of Biology; Cell and Gene Technology Group, Institute of Gene Biology, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: ashunaeva@gmail.com
Ресей, Moscow, 119991; Moscow, 119334

A. Atemasova

Moscow State University, Faculty of Biology

Email: ashunaeva@gmail.com
Ресей, Moscow, 119991

A. Filatov

National Research Center—Institute of Immunology of Federal Medical-Biological Agency of Russia

Email: ashunaeva@gmail.com
Ресей, Moscow, 115478

D. Mazurov

Cell and Gene Technology Group, Institute of Gene Biology, Russian Academy of Sciences; National Research Center—Institute of Immunology of Federal Medical-Biological Agency of Russia

Email: ashunaeva@gmail.com
Ресей, Moscow, 119334; Moscow, 115478

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© Pleiades Publishing, Inc., 2019