ZNF143 is involved in CTCF-mediated chromatin interactions by cooperation with cohesin and other partners


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

ZNF143 is a ubiquitously expressed transcription factor conserved in vertebrates and might regulate the expression of numerous genes. But its function in mediating chromatin interactions remains elusive. By integrated analysis of public datasets, we provided evidence that a majority of ZNF143 binding sites (BSs) were involved in CTCF-mediated chromatin interaction networks (CTCF-CINs) by overlapping with cohesin-BSs and CTCF-BSs. We further showed that only a very few CTCF-CINs were associated with ZNF143 alone, whereas those associated with ZNF143 and cohesin simultaneously were highly overlapped with constitutive, conserved CTCF-BSs and enriched at boundaries of chromatin topologically associating domains. These observations implicate that as an important partner of CTCF, ZNF143 helps it establish the conserved chromatin structure by cooperating with cohesin.

Негізгі сөздер

Авторлар туралы

B.-Y. Ye

College of Life Sciences; Beijing Institute of Biotechnology

Email: zhaozh@nic.bmi.ac.cn
ҚХР, 105 Xisanhuanbei Road, Haidian District, Beijing, 100048; No. 20, Dongdajie Street, Fengtai District, Beijing, 100071

W.-L. Shen

Beijing Institute of Biotechnology

Email: zhaozh@nic.bmi.ac.cn
ҚХР, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071

D. Wang

Beijing Institute of Biotechnology

Email: zhaozh@nic.bmi.ac.cn
ҚХР, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071

P. Li

Beijing Institute of Biotechnology

Email: zhaozh@nic.bmi.ac.cn
ҚХР, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071

Z. Zhang

Beijing Institute of Biotechnology

Email: zhaozh@nic.bmi.ac.cn
ҚХР, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071

M.-L. Shi

Beijing Institute of Biotechnology

Email: zhaozh@nic.bmi.ac.cn
ҚХР, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071

Y. Zhang

Beijing Institute of Biotechnology

Email: zhaozh@nic.bmi.ac.cn
ҚХР, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071

F.-X. Zhang

College of Life Sciences

Хат алмасуға жауапты Автор.
Email: fxzhang@hotmail.com
ҚХР, 105 Xisanhuanbei Road, Haidian District, Beijing, 100048

Z.-H. Zhao

Beijing Institute of Biotechnology

Хат алмасуға жауапты Автор.
Email: zhaozh@nic.bmi.ac.cn
ҚХР, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Pleiades Publishing, Inc., 2016