Mitochondrial DNA deletion Δ4977 in peptic ulcer disease
- Authors: Salehi Z.1, Haghighi A.2, Haghighi S.3, Aminian K.4, Asl S.F.4, Mashayekhi F.1
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Affiliations:
- Department of Biology
- University of Guilan
- Department of Biology/Genetic, Tabrize Branch
- Guilan University of Medical Sciences
- Issue: Vol 51, No 1 (2017)
- Pages: 30-33
- Section: Genomics. Transcriptomics
- URL: https://journals.rcsi.science/0026-8933/article/view/162949
- DOI: https://doi.org/10.1134/S0026893317010162
- ID: 162949
Cite item
Abstract
Reactive oxygen species (ROS) play a critical role in peptic ulcer disease (PUD). Due to the high rate of ROS production and limited capacity for DNA repair within mitochondria, mtDNA is susceptible to oxidative damage and mutations. mtDNA deletion Δ4977 is one of the most common deletion events identified in mitochondria. We examined the association of 4977-bp mtDNA deletion with PUD. Genotypes were determined in bioptic samples of 150 PUD patients and 190 controls. The 4977-bp mtDNA deletion was found more frequently among patients with PUD (52%) than among controls (22.63%). The strong association between the mtDNA 4977-bp deletion and PUD was confirmed (OR = 3.7; 95% CI, 2.32–5.91; P = 0.0001). The 4977-bp deletion in mitochondrial DNA may be a risk factor for PUD, or may reflect an increase in oxidative stress that commonly accompanies underlying PUD disease. Larger population-based studies are needed to uncover the possible causal relationship between this deletion and peptic ulcer disease.
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About the authors
Z. Salehi
Department of Biology
Author for correspondence.
Email: geneticzs@yahoo.co.uk
Iran, Islamic Republic of, Rasht
A. Haghighi
University of Guilan
Email: geneticzs@yahoo.co.uk
Iran, Islamic Republic of, Rasht
S. Haghighi
Department of Biology/Genetic, Tabrize Branch
Email: geneticzs@yahoo.co.uk
Iran, Islamic Republic of, Tabrize
K. Aminian
Guilan University of Medical Sciences
Email: geneticzs@yahoo.co.uk
Iran, Islamic Republic of, Rasht
S. F. Asl
Guilan University of Medical Sciences
Email: geneticzs@yahoo.co.uk
Iran, Islamic Republic of, Rasht
F. Mashayekhi
Department of Biology
Email: geneticzs@yahoo.co.uk
Iran, Islamic Republic of, Rasht