Analysis of the association of interleukin 4 and interleukin 10 gene variants with basic personality traits
- Authors: Golimbet V.E.1, Alfimova M.V.1, Korovaitseva G.I.1, Lezheiko T.V.1
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Affiliations:
- Mental Health Research Center
- Issue: Vol 50, No 6 (2016)
- Pages: 839-844
- Section: Genomics. Transcriptomics
- URL: https://journals.rcsi.science/0026-8933/article/view/162876
- DOI: https://doi.org/10.1134/S0026893316060054
- ID: 162876
Cite item
Abstract
There is growing evidence that serum levels of various inflammation markers are associated with personality traits. However, only few studies investigated the link between genetic variants of cytokine encoding genes and psychological characteristics. In this study, we examined genotypes in 297 individuals to assess the association between common variants of interleukin 4 (IL-4) and interleukin 10 (IL-10) genes and basic personality traits of extraversion and neuroticism, measured using the Eysenck Personality Questionnaire (EPQ). We found that, in homozygous female carriers of high expression alleles Т (IL-4 C-589T) and G (IL-10 G-1082A), neuroticism scores were higher (p = 0.045 and p = 0.08, respectively). In turn, extraversion scores were significantly higher in both male and female carriers of heterozygous variants CT and GA (p = 0.01). Our results are in accordance with the behavioral immune system hypothesis, and the general paradigm on the role of personality traits in health and longevity.
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About the authors
V. E. Golimbet
Mental Health Research Center
Author for correspondence.
Email: golimbet@mail.ru
Russian Federation, Moscow, 117152
M. V. Alfimova
Mental Health Research Center
Email: golimbet@mail.ru
Russian Federation, Moscow, 117152
G. I. Korovaitseva
Mental Health Research Center
Email: golimbet@mail.ru
Russian Federation, Moscow, 117152
T. V. Lezheiko
Mental Health Research Center
Email: golimbet@mail.ru
Russian Federation, Moscow, 117152