Structural Reorganization of Cell Membrane Models Caused by the Anticancer Antibiotic Doxorubicin
- Autores: Novikova N.1, Kovalchuk M.1, Rogachev A.1, Malakhova Y.1,2, Kotova Y.3, Gelperina S.3, Yakunin S.1
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Afiliações:
- National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
- MIREA—Rusian Technological University, Moscow, Russia
- Mendeleev University of Chemical Technology, 125047, Moscow, Russia
- Edição: Volume 68, Nº 6 (2023)
- Páginas: 990-1001
- Seção: ПОВЕРХНОСТЬ, ТОНКИЕ ПЛЕНКИ
- URL: https://journals.rcsi.science/0023-4761/article/view/231852
- DOI: https://doi.org/10.31857/S0023476123600842
- EDN: https://elibrary.ru/AAUWIR
- ID: 231852
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Resumo
The molecular mechanisms of the interaction of anticancer antibiotic doxorubicin with lipid cell membrane models have been investigated using grazing incidence X-ray diffraction (XRD) and X-ray reflectivity (XRR). The model systems were monolayers of four types of phospholipids, related to the main components of animal cell membranes. New information on the processes of damage of phospholipid monolayer lattice caused by doxorubicin is obtained. It is established that the action of doxorubicin on anionic phospholipid monolayers is determined by the electrostatic interaction: positively charged doxorubicin molecules are incorporated between negatively charged phospholipid functional groups. In the case of neutral phospholipids the key role belongs to the hydrophobic interaction: doxorubicin molecules are coordinated with phospholipid hydrocarbon tails in disordered regions.
Sobre autores
N. Novikova
National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
Email: nn-novikova07@yandex.ru
Россия, Москва
M. Kovalchuk
National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
Email: nn-novikova07@yandex.ru
Россия, Москва
A. Rogachev
National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
Email: nn-novikova07@yandex.ru
Россия, Москва
Yu. Malakhova
National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia; MIREA—Rusian Technological University, Moscow, Russia
Email: nn-novikova07@yandex.ru
Россия, Москва; Россия, Москва
Yu. Kotova
Mendeleev University of Chemical Technology, 125047, Moscow, Russia
Email: nn-novikova07@yandex.ru
Россия, Москва
S. Gelperina
Mendeleev University of Chemical Technology, 125047, Moscow, Russia
Email: nn-novikova07@yandex.ru
Россия, Москва
S. Yakunin
National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
Autor responsável pela correspondência
Email: nn-novikova07@yandex.ru
Россия, Москва
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