Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

I. A. Kolesnikov; Колесников И. А.; V. I. Timofeev; Тимофеев В. И.; A. V. Ermakov; Ермаков А. В.; A. S. Ivanovsky; Ивановский А. С.; Yu. A. Dyakova; Дьякова Ю. А.; Yu. V. Pisarevsky; Писаревский Ю. В.; M. V. Kovalchuk; Ковальчук М. В.

doi:10.31857/S0023476123600179

Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

Autores: Kolesnikov I.¹, Timofeev V.¹^,2, Ermakov A.¹, Ivanovsky A.², Dyakova Y.¹, Pisarevsky Y.²^,1, Kovalchuk M.¹^,2
Afiliações:
1. National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
2. Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia
Edição: Volume 68, Nº 6 (2023)
Páginas: 971-978
Seção: КРИСТАЛЛОГРАФИЯ В БИОЛОГИИ И МЕДИЦИНЕ
URL: https://journals.rcsi.science/0023-4761/article/view/231848
DOI: https://doi.org/10.31857/S0023476123600179
EDN: https://elibrary.ru/HJNXSQ
ID: 231848

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Resumo

The spatial structure of the envelope protein of African swine fever (ASF) virus is modeled; its topology relative to the cell membrane is calculated; the B- and T-cell epitopes are predicted for this protein; and their immunogenecity, allergenicity, and toxicity are estimated. The variability of protein amino acids and the conservativity of the found epitopes are studied. It is shown that a new peptide vaccine against ASF can be developed based on the found epitopes.

Sobre autores

I. Kolesnikov

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

V. Timofeev

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

A. Ermakov

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

A. Ivanovsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

Yu. Dyakova

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

Yu. Pisarevsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia; National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

M. Kovalchuk

Autor responsável pela correspondência
Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

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