Search for New Potential T-Cell and B-Cell Epitopes in the Spike Protein of SARS-CoV-2

I. A. Kolesnikov; Колесников И. А.; V. I. Timofeev; Тимофеев В. И.; M. V. Nikolenko; Николенко М. В.; A. V. Ermakov; Ермаков А. В.; A. S. Ivanovsky; Ивановский А. С.; Yu. A. Dyakova; Дьякова Ю. А.; Yu. V. Pisarevsky; Писаревский Ю. В.; M. V. Kovalchuk; Ковальчук М. В.

doi:10.31857/S0023476123600106

Search for New Potential T-Cell and B-Cell Epitopes in the Spike Protein of SARS-CoV-2

作者: Kolesnikov I.A.¹, Timofeev V.I.¹^,2, Nikolenko M.V.¹, Ermakov A.V.¹, Ivanovsky A.S.², Dyakova Y.A.¹, Pisarevsky Y.V.²^,1, Kovalchuk M.V.¹^,2
隶属关系:
1. National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
2. Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia
期: 卷 68, 编号 6 (2023)
页面: 959-970
栏目: КРИСТАЛЛОГРАФИЯ В БИОЛОГИИ И МЕДИЦИНЕ
URL: https://journals.rcsi.science/0023-4761/article/view/231847
DOI: https://doi.org/10.31857/S0023476123600106
EDN: https://elibrary.ru/YEZWPQ
ID: 231847

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详细

The current epidemiological situation, including the existence of new SARS-CoV-2 virus with a high mutagenicity, requires fundamentally new deadlines for the development of vaccines, which may be achieved only applying modern computing technologies and simulation. Epitopes have been found in the spike protein of the SARS-CoV-2 virus using immunoinformatics methods, and their allergenicity and immunogenecity was predicted. It is shown that a vaccine against SARS-CoV-2 can be designed based on these epitopes.

参考

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