ПОЛИМЕРНЫЕ МИЦЕЛЛЫ ДЛЯ НАНОМЕДИЦИНЫ: КАК ПОВЫСИТЬ ИХ УСТОЙЧИВОСТЬ?

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Аннотация

Полимерные мицеллы остаются активно изучаемыми объектами в области наномедицины, включая фармакотерапию рака, на протяжении нескольких десятилетий. Благодаря своей структуре «ядро–корона», регулируемым параметрам (размеру, форме, сорбционной емкости, скорости деградации и др.), способности придавать стимул-чувствительные свойства и пр. полимерные мицеллы зарекомендовали себя как перспективные носители, способные эффективно инкапсулировать различные лекарственные вещества, доставлять их в целевые ткани и органы, обеспечивая при этом контролируемое и пролонгированное высвобождение. Несмотря на многочисленные исследования, на сегодняшний день в разных странах мира одобрено всего четыре нанопрепарата на основе полимерных мицелл для лечения рака. В представленном обзоре обсуждается один из существенных недостатков полимерных мицелл как носителей лекарств, а именно возможность их распада на неассоциированные макромолекулы при разбавлении и/или изменении условий окружающей среды (pH, температуры, ионной силы раствора), и рассматриваются некоторые стратегии, используемые для устранения этого недостатка, связанного с недостаточной термодинамической стабильностью. К этим стратегиям относятся химическая сшивка полимерных цепей, формирующих ядро или корону мицелл, физическая сшивка сегментов мицелл за счет дополнительных гидрофобных, электростатических взаимодействий или стереокомплексообразования, а также образование мономолекулярных мицелл.

Об авторах

Е. В Кузнецова

Национальный исследовательский центр «Курчатовский институт»; Институт синтетических полимерных материалов им. Н.С. Ениколопова РАН

Email: kuznetsova.kate992@gmail.com
Москва, Россия

С. Н Чвалун

Национальный исследовательский центр «Курчатовский институт»; Институт синтетических полимерных материалов им. Н.С. Ениколопова РАН

Москва, Россия

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