MODELLING OF NANOEMULSION STABILITY IN eLIPOSOMES

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Abstract

eLiposomes are O/W nanoemulsions encapsulated within the inner pool of liposomes. The main challenge in developing these systems is understanding how different structures are formed in the confined space of liposomes. In this study, we proposed a method for calculating the forces of attraction and repulsion between an oil droplet and the inner surface of a hollow sphere, aiming to model the interior of liposomes. The motion and interaction of the oil droplets with the inner surface of the liposome were modelled using Langevin dynamics. At a low liposome charge of –10 mV, oil droplets were adsorbed onto the inner surface of liposomes, forming structures that can be referred to as inverted colloidosomes. If the charge on the oil droplets in the nanoemulsion was also low and equal to –10 mV, the adsorbed oil droplets formed regions of dense hexagonal packing on the inner surface of the liposomes. If the charge on the oil droplets in the nanoemulsion was high and equal to –50 mV, the droplets repelled each other and were located at some distance, resulting in sparse packing on the inner surface of the liposomes. Multicompartment systems, such as inverted colloidosomes, are promising carriers for hydrophobic, hydrophilic and amphiphilic drug compounds.

About the authors

A. A Bazurov

Mendeleev University of Chemical Technology

Moscow, Russia

M. Yu. Koroleva

Mendeleev University of Chemical Technology

Email: m.yu.kor@gmail.com
Moscow, Russia

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