电邮这篇文章 Effect of gamma irradiation dose on papain toxicity
- 作者: Allayarova U.Y.1, Demidov S.V.1, Blokhina S.V.1, Rayevskaya T.A.1, Mishchenko D.V.1, Omelchuk Y.A.2, Allayarov S.R.1
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隶属关系:
- Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
- Sevastopol National University
- 期: 卷 58, 编号 5 (2024)
- 页面: 404-411
- 栏目: RADIATION CHEMISTRY
- URL: https://journals.rcsi.science/0023-1193/article/view/280939
- DOI: https://doi.org/10.31857/S0023119324050097
- EDN: https://elibrary.ru/TXKSIN
- ID: 280939
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详细
Study of the effect of a wide range of γ-irradiation doses from 250 to 3000 kGy on acute toxicity of papain when administered to laboratory animals. It was found for the first time that preliminary γ-irradiation of papain up to 1000 kGy reduces toxicity of its aqueous dispersions at intraperitoneal administration by more than five times. Further increase of irradiation dose up to 3000 kGy does not lead to a noticeable change in the toxic effect. The results of the study indicate that γ-irradiation of papain can be used to reduce its toxicity.
作者简介
U. Allayarova
Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: sadush@icp.ac.ru
俄罗斯联邦, Chernogolovka
S. Demidov
Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: sadush@icp.ac.ru
俄罗斯联邦, Chernogolovka
S. Blokhina
Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: sadush@icp.ac.ru
俄罗斯联邦, Chernogolovka
T. Rayevskaya
Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: sadush@icp.ac.ru
俄罗斯联邦, Chernogolovka
D. Mishchenko
Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
Email: sadush@icp.ac.ru
俄罗斯联邦, Chernogolovka
Yu. Omelchuk
Sevastopol National University
Email: sadush@icp.ac.ru
Sevastopol Institute for Nuclear Energy and Industry
俄罗斯联邦, SevastopolS. Allayarov
Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: sadush@icp.ac.ru
俄罗斯联邦, Chernogolovka
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