Two Novel Ca(II)-Carboxylate Coordination Polymers: Crystal Structures and Antimyeloma Activity Evaluation

Abstract

In this study, two new coordination polymers [Ca₃(BTB)₂(NMP)₂(H₂O)₂](NMP)(H₂O)₄ (1, H₃BTB = benzene-1,3,5-tribenzoic acid, NMP = N-methyl-pyrrolidone) and [Ca₃(NTB)₂(DEF)₂(H₂O)₂] (DEF)(H₂O)₄ (2, H₃NTB = 4,4′,4″-nitrilotribenzoic acid, DEF = N,N-diethyl-formamide) based on the alkaline earth metal Ca(II) ion and two rigid C₃-symmetric tricarboxylic acid ligands are successfully prepared via the solvothermal reaction. The structural analysis of complexes 1 and 2 demonstrates the existence of different topologies and structures in the as-prepared complexes because of the conformational flexibility of the organic ligands and the diverse geometry of the Ca(II)-based 1D secondary building unit. The particle sizes of these two complexes could be conveniently downsized in nanometer region via a simple treatment. In addition, in vitro anticancer activity of compounds 1 and 2 in nanometer has been studied for inhibition human myeloma cell growth via the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay.