Three New Metal-Organic Coordination Complexes: Crystal Structures and Anticancer Activity in Multiple Myeloma

Abstract

Three new metal-organic coordination complexes, namely [Cu(4,4′-bipy)₂(NCS)₂]_n (I), [Cu(HCOO)₂(4,4′—bipy)] (II), and [Cu(2,2′-bipy)₂]₂(V₆O₁₇) (III) (4,4′-bipy and 2,2′-bipy = 4,4′-bipyridine and 2,2′-bipyridine, respectively) are successfully prepared by using two similar pyridine ligands with different orientations of N atoms under different reaction conditions (slow volatilization for I, solvothermal for II and III). Their structures and compositions are characterized by both single crystal X-ray diffraction and elemental analysis. Additionally, the newly synthesized compounds are evaluated to identify the molecular characteristics contributing to their cytotoxicity. They are tested against three human multiple myeloma cells (NCI-H929, MM1S, and MM1R) with the MTT assay.