Отправить статью по E-mail Structure, DNA bonding, and biological activity of a novel Pb(II) complex of 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane
- Авторы: Gao E.1, Meng B.1, Su J.1, Peng T.1, Qi Z.1, Jia B.1, Feng Y.1, Zhu M.1
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Учреждения:
- Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
- Выпуск: Том 58, № 8 (2017)
- Страницы: 1560-1566
- Раздел: Article
- URL: https://journals.rcsi.science/0022-4766/article/view/161706
- DOI: https://doi.org/10.1134/S0022476617080121
- ID: 161706
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Аннотация
A novel complex [Pb(bptm)(NO3)(H2O)2] (bptm = 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane) is synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction. Its reactivity with calf thymus DNA and HeLa cell DNA is measured using UV absorption and fluorescence spectroscopies. Gel electrophoresis assay demonstrates the ability of the complex to cleave pBR322 plasmid DNA. Eventually, the complex can suitably dock with a special DNA.
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Об авторах
E.-J. Gao
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
Китай, Shenyang
B. Meng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
Китай, Shenyang
J.-Q. Su
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
Китай, Shenyang
T.-T. Peng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
Китай, Shenyang
Z.-Z. Qi
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
Китай, Shenyang
B. Jia
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
Китай, Shenyang
Y.-H. Feng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
Китай, Shenyang
M.-C. Zhu
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Автор, ответственный за переписку.
Email: mczhu@syuct.edu.cn
Китай, Shenyang
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