The Rat (Rattus norvegicus) as a Model Object for Acute Organophosphate Poisoning. 1. Biochemical Aspects
- 作者: Goncharov N.1,2, Terpilowski M.2, Shmurak V.1, Belinskaya D.2, Avdonin P.3
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隶属关系:
- Research Institute of Hygiene, Occupational Pathology and Human Ecology
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- Koltsov Institute of Developmental Biology
- 期: 卷 55, 编号 2 (2019)
- 页面: 112-123
- 栏目: Comparative and Ontogenic Biochemistry
- URL: https://journals.rcsi.science/0022-0930/article/view/159699
- DOI: https://doi.org/10.1134/S0022093019020042
- ID: 159699
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详细
The long-term effects of acute organophosphate (OP) poisoning remain poorly studied, while experimental models usually disregard species-related specificity of rodents as model objects. Here we present two toxicological models and a comparative analysis of a wide range of biochemical blood indices in their dynamics over 3 months after acute rat poisoning with paraoxon. As expected, the most sensitive biochemical index within the first hours and days after OP poisoning was whole blood acetylcholinesterase activity, which decreased by almost an order of magnitude in all experimental groups 3 h after poisoning. Changes in the parameters of carbohydrate and fat metabolism (triglyceride, free fatty acid, D-3-hydroxybutyrate, cholesterol and glycerol levels) were detected in experimental groups at different time points after poisoning. Statistically significant changes in a number of biochemical markers were found in positive control rats relative to intact rodents.
作者简介
N. Goncharov
Research Institute of Hygiene, Occupational Pathology and Human Ecology; Sechenov Institute of Evolutionary Physiology and Biochemistry
编辑信件的主要联系方式.
Email: ngoncharov@gmail.com
俄罗斯联邦, St. Petersburg; St. Petersburg
M. Terpilowski
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: ngoncharov@gmail.com
俄罗斯联邦, St. Petersburg
V. Shmurak
Research Institute of Hygiene, Occupational Pathology and Human Ecology
Email: ngoncharov@gmail.com
俄罗斯联邦, St. Petersburg
D. Belinskaya
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: ngoncharov@gmail.com
俄罗斯联邦, St. Petersburg
P. Avdonin
Koltsov Institute of Developmental Biology
Email: ngoncharov@gmail.com
俄罗斯联邦, Moscow