Blood–brain barrier and evolution of peptide regulation of physiological functions
- 作者: Mar’yanovich A.1
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隶属关系:
- Mechnikov North-West State Medical University
- 期: 卷 52, 编号 4 (2016)
- 页面: 326-334
- 栏目: Problem Papers
- URL: https://journals.rcsi.science/0022-0930/article/view/159082
- DOI: https://doi.org/10.1134/S0022093016040074
- ID: 159082
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详细
Literature and own data on central effects of regulatory peptides (155 substances from 32 families) have been analyzed. Peptides produced by peripheral tissues affect the brain through the almost impermeable for them blood–brain barrier and evoke numerous central effects. The mechanisms of this impact are as follows: peptides bind to specific receptors located on vagal afferent terminals and in the circumventricular organs as well as (to a lesser extent) penetrate into the brain with the aid of specific transport systems or by simple diffusion. The number of these trans-barrier communications depends on the evolutionary age of the regulated physiological function: the more ancient the function is, the greater number of peripheral peptides are involved in such trans-barrier communications.
作者简介
A. Mar’yanovich
Mechnikov North-West State Medical University
编辑信件的主要联系方式.
Email: atm52@mail.ru
俄罗斯联邦, St. Petersburg