Changes in sleep characteristics of rat preclinical model of Parkinson’s disease based on attenuation of the ubiquitin—proteasome system activity in the brain


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

Numerous experimental and epidemiological data indicate a high significance of environmental neurotoxins, specifically, inhibitors of the ubiquitin–proteasome system, in pathogenesis of Parkinson’s disease (PD). To develop a preclinical model of PD in rats we used a technique of intranasal administration of lactacystin, a natural proteasome inhibitor, into the brain. It was found that three weeks after the first lactacystin administration it induced a little degeneration of dopaminergic neurons in the olfactory bulb and substantia nigra pars compacta without any olfactory dysfunction and motor behavior disorders. Besides, its effect led to the appearance of some signs of sleep disorders: increased somnolence (especially in the dark, active daily phase), fragmentation of slow-wave sleep, decreased EEG delta rhythm during slow-wave sleep. These signs share some similarity with PD and could be useful in clinical studies for the quick search for polysomnographic markers of the early PD stage.

Sobre autores

I. Ekimova

Sechenov Institute of Evolutionary Physiology and Biochemistry

Autor responsável pela correspondência
Email: irina-ekimova@mail.ru
Rússia, St. Petersburg

V. Simonova

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: irina-ekimova@mail.ru
Rússia, St. Petersburg

M. Guzeev

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: irina-ekimova@mail.ru
Rússia, St. Petersburg

K. Lapshina

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: irina-ekimova@mail.ru
Rússia, St. Petersburg

M. Chernyshev

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: irina-ekimova@mail.ru
Rússia, St. Petersburg

Yu. Pastukhov

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: irina-ekimova@mail.ru
Rússia, St. Petersburg

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Pleiades Publishing, Ltd., 2016