Changes in sleep characteristics of rat preclinical model of Parkinson’s disease based on attenuation of the ubiquitin—proteasome system activity in the brain
- Autores: Ekimova I.V.1, Simonova V.V.1, Guzeev M.A.1, Lapshina K.V.1, Chernyshev M.V.1, Pastukhov Y.F.1
-
Afiliações:
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- Edição: Volume 52, Nº 6 (2016)
- Páginas: 463-474
- Seção: Comparative and Ontogenic Physiology
- URL: https://journals.rcsi.science/0022-0930/article/view/159166
- DOI: https://doi.org/10.1134/S1234567816060057
- ID: 159166
Citar
Resumo
Numerous experimental and epidemiological data indicate a high significance of environmental neurotoxins, specifically, inhibitors of the ubiquitin–proteasome system, in pathogenesis of Parkinson’s disease (PD). To develop a preclinical model of PD in rats we used a technique of intranasal administration of lactacystin, a natural proteasome inhibitor, into the brain. It was found that three weeks after the first lactacystin administration it induced a little degeneration of dopaminergic neurons in the olfactory bulb and substantia nigra pars compacta without any olfactory dysfunction and motor behavior disorders. Besides, its effect led to the appearance of some signs of sleep disorders: increased somnolence (especially in the dark, active daily phase), fragmentation of slow-wave sleep, decreased EEG delta rhythm during slow-wave sleep. These signs share some similarity with PD and could be useful in clinical studies for the quick search for polysomnographic markers of the early PD stage.
Palavras-chave
Sobre autores
I. Ekimova
Sechenov Institute of Evolutionary Physiology and Biochemistry
Autor responsável pela correspondência
Email: irina-ekimova@mail.ru
Rússia, St. Petersburg
V. Simonova
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: irina-ekimova@mail.ru
Rússia, St. Petersburg
M. Guzeev
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: irina-ekimova@mail.ru
Rússia, St. Petersburg
K. Lapshina
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: irina-ekimova@mail.ru
Rússia, St. Petersburg
M. Chernyshev
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: irina-ekimova@mail.ru
Rússia, St. Petersburg
Yu. Pastukhov
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: irina-ekimova@mail.ru
Rússia, St. Petersburg
Arquivos suplementares
