Perinatal Hypoxia-Induced Impairments of Behavioral and Hormonal Stress Responses in Rats and Their Correction by a Novel GABA Derivative
- Authors: Ordyan N.E.1, Akulova V.K.1, Pivina S.G.1, Otellin V.A.1, Tyurenkov I.N.2
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Affiliations:
- Pavlov Institute of Physiology
- Volgograd State Medical University
- Issue: Vol 55, No 1 (2019)
- Pages: 64-70
- Section: Comparative and Ontogenic Physiology
- URL: https://journals.rcsi.science/0022-0930/article/view/159676
- DOI: https://doi.org/10.1134/S0022093019010083
- ID: 159676
Cite item
Abstract
The negative long-term effects of hypoxic exposure on postnatal day 2 (human incomplete pregnancy model) on behavior (open field test) and activity of the hypothalamic-pituitary-adrenal (HPA) axis were studied in pubertal rats together with the possibility of their correction by post-hypoxic administration of a GABA derivative salifen (an adduct of γ-amino-β-phenylbutyric acid and salicylic acid). It was shown that perinatal hypoxic exposure impairs the inhibitory mechanisms in the CNS as manifested in the absence of motor activity inhibition in the open field as well as in the enhanced and prolonged stress response of the HPA axis. Post-hypoxic administration of salifen (15 mg/kg) for 14 days restored efficiently the inhibitory processes except for persistently increased hormonal stress reactivity of the HPA axis. Possible mechanisms underlying the therapeutic effects of salifen are discussed.
About the authors
N. E. Ordyan
Pavlov Institute of Physiology
Author for correspondence.
Email: neo@infran.ru
Russian Federation, St. Petersburg
V. K. Akulova
Pavlov Institute of Physiology
Email: neo@infran.ru
Russian Federation, St. Petersburg
S. G. Pivina
Pavlov Institute of Physiology
Email: neo@infran.ru
Russian Federation, St. Petersburg
V. A. Otellin
Pavlov Institute of Physiology
Email: neo@infran.ru
Russian Federation, St. Petersburg
I. N. Tyurenkov
Volgograd State Medical University
Email: neo@infran.ru
Russian Federation, Volgograd