Production of Lidocaine Nanoforms via the Rapid Extension of a Supercritical Solution into Water Medium

Abstract

The pharmaceutical substances of a group of local anesthetics, in particular, the drug lidocaine, are the object of the study. The influence of the thermodynamic parameters of the state on the process of lidocaine dispersion via the rapid expansion of a supercritical solution in an aqueous medium (RESAS) is studied in this work. The experiments were carried out at saturation temperatures of 40 and 60°C, a temperature of the expansion device of 40°C, and a system pressure of 15–35 MPa. The structure of the obtained particles was analyzed with a D8 ADVANCE diffractometer (before and after grinding). The melting points of the initial and processed lidocaine substance were determined.