Genetics and Epigenetics of Nonsuicidal Self-Injury: a Narrative Review
- 作者: Kibitov А.1,2, Mazo G.2
-
隶属关系:
- Mental Health Research Center
- Bekhterev National Medical Research Center for Psychiatry and Neurology
- 期: 卷 59, 编号 12 (2023)
- 页面: 1347-1359
- 栏目: ОБЗОРНЫЕ И ТЕОРЕТИЧЕСКИЕ СТАТЬИ
- URL: https://journals.rcsi.science/0016-6758/article/view/233632
- DOI: https://doi.org/10.31857/S0016675823120032
- EDN: https://elibrary.ru/QDPGGW
- ID: 233632
如何引用文章
详细
Nonsuicidal self-injury (NSSI), or self-harm is widely spread, especially among the young people. However, despite the problem’s relevance, NSSI was investigated mainly from the psychological and social perspective, while a fairly small number of biological studies of NSSI have been published to date. The aim of this narrative review was to analyze all the currently available publications on the genetics and epigenetics of NSSI – one of the most promising areas in biological research. We discussed and analyzed all stages of genetic research of NSSI: from twin studies and studies of self-harm in the framework of hereditary diseases to candidate genes, genome-wide, epigenetic and gene-environment interactions studies. We demonstrated data indicating significant contribution of genetic and epigenetic factors to the development of NSSI, discussed advantages and limitations of analyzed studies, outlined prospects for further research in this area.
作者简介
А. Kibitov
Mental Health Research Center; Bekhterev National Medical Research Center for Psychiatry and Neurology
编辑信件的主要联系方式.
Email: andreykibitov18@gmail.com
Russia, 115522, Moscow; Russia, 192019, Saint-Petersburg
G. Mazo
Bekhterev National Medical Research Center for Psychiatry and Neurology
Email: andreykibitov18@gmail.com
Russia, 192019, Saint-Petersburg
参考
- International Society for the Study of Self-Injury. What is Non-Suicidal Self-Injury? 2022. https://www.itriples.org/what-is-nssi
- Swannell S.V., Martin G.E., Page A. et al. Prevalence of nonsuicidal self-injury in nonclinical samples: Systematic review, meta-analysis and meta-regression // Suicide Life-Threatening Behav. 2014. V. 44. № 3. P. 273–303. https://doi.org/10.1111/sltb.12070
- Cheng H., Wang D., Wang L. et al. Global prevalence of self-harm during the COVID-19 pandemic: A systematic review and meta-analysis // BMC Psychol. 2023. V. 11. № 1. P. 149. https://doi.org/10.1186/s40359-023-01181-8
- Grandclerc S., De Labrouhe D., Spodenkiewicz M. et al. Relations between nonsuicidal self-injury and suicidal behavior in adolescence: A systematic review // PLoS One. 2016. V. 11. № 4. https://doi.org/10.1371/journal.pone.0153760
- Kaess M., Hooley J.M., Klimes-Dougan B. et al. Advancing a temporal framework for understanding the biology of nonsuicidal self-injury: An expert review // Neurosci. Biobehav. Rev. 2021. V. 130. P. 228–239. https://doi.org/10.1016/j.neubiorev.2021.08.022
- Oliver C., Richards C. Self-injurious behaviour in people with intellectual disability // Curr. Opin. Psychiatry. 2010. V. 23. № 5. P. 412–416. https://doi.org/10.1097/YCO.0b013e32833cfb80
- Huisman S., Mulder P., Kuijk J. et al. Self-injurious behavior // Neurosci. Biobehav. Rev. 2018. V. 84. P. 483–491. https://doi.org/10.1016/j.neubiorev.2017.02.027
- Arron K., Oliver C., Moss J. et al. The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes // J. Intellect. Disabil. Res. 2011. V. 55. № 2. P. 109–120. https://doi.org/10.1111/j.1365-2788.2010.01337.x
- Lesch M., Nyhan W.L. A familial disorder of uric acid metabolism and central nervous system function // Am. J. Med. 1964. V. 36. № 4. P. 561–570. https://doi.org/10.1016/0002-9343(64)90104-4
- Harris J.C. Lesch–Nyhan syndrome and its variants: Examining the behavioral and neurocognitive phenotype // Curr. Opin. Psychiatry. 2018. V. 31. № 2. P. 96–102. https://doi.org/10.1097/YCO.0000000000000388
- Palmour R.M. Genetic models for the study of aggressive behavior // Prog. Neuro-Psychopharmacology Biol. Psychiatry. 1983. V. 7. № 4–6. P. 513–517. https://doi.org/10.1016/0278-5846(83)90018-0
- Ortiz R., Ulrich H., Zarate C.A., Machado-Vieira R. Purinergic system dysfunction in mood disorders: A key target for developing improved therapeutics // Prog. Neuro-Psychopharmacology Biol. Psychiatry. 2015. V. 57. P. 117–131. https://doi.org/10.1016/j.pnpbp.2014.10.016
- Gonçalves M.C.B., Corrêa-Velloso J., Naaldijk Y. et al. Purinergic modulation of pathways associated to suicidal behavior // Mol. Psychiatry. 2020. V. 25. № 3. P. 514–516. https://doi.org/10.1038/s41380-018-0088-3
- Mrug S., Mrug M. Uric acid excretion predicts increased aggression in urban adolescents // Physiol. Behav. 2016. V. 163. P. 144–148. https://doi.org/10.1016/j.physbeh.2016.05.014
- Deliberto T.L., Nock M.K. An exploratory study of correlates, onset, and offset of non-suicidal self-injury // Arch. Suicide Res. 2008. V. 12. № 3. P. 219–231. https://doi.org/10.1080/13811110802101096
- Kandsperger S., Jarvers I., Ecker A. et al. Emotional reactivity and family-related factors associated with self-injurious behavior in adolescents presenting to a child and adolescent psychiatric emergency service // Front. Psychiatry. 2021. V. 12. https://doi.org/10.3389/fpsyt.2021.634346
- Jang K.L., Livesley W.J., Vernon P.A., Jackson D.N. Heritability of personality disorder traits: A twin study // Acta Psychiatr. Scand. 1996. V. 94. № 6. P. 438–444. https://doi.org/10.1111/j.1600-0447.1996.tb09887.x
- Vernon P.A., McCarthy J.M., Johnson A.M. et al. Individual differences in multiple dimensions of aggression: A univariate and multivariate genetic analysis // Twin Res. 1999. V. 2. № 1. P. 16–21. https://doi.org/10.1375/136905299320566068
- Distel M.A., Willemsen G., Ligthart L. et al. Genetic covariance structure of the four main features of borderline personality disorder // J. Pers. Disord. 2010. V. 24. № 4. P. 427–444. https://doi.org/10.1521/pedi.2010.24.4.427
- Althoff R.R., Hudziak J.J., Willemsen G. et al. Genetic and environmental contributions to self-reported thoughts of self-harm and suicide // Am. J. Med. Genet. Part B Neuropsychiatr. Genet. 2012. V. 159 B. № 1. P. 120–127. https://doi.org/10.1002/ajmg.b.32010
- Maciejewski D.F., Creemers H.E., Lynskey M.T. et al. Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation // JAMA Psychiatry. 2014. V. 71. № 6. P. 699. https://doi.org/10.1001/jamapsychiatry.2014.89
- Few L.R., Werner K.B., Sartor C.E. et al. Early onset alcohol use and self-harm: A discordant twin analysis // Alcohol. Clin. Exp. Res. 2015. V. 39. № 11. P. 2134–2142.https://doi.org/10.1111/acer.12889
- Richmond-Rakerd L.S., Trull T.J., Gizer I.R. et al. Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors // Psychol. Med. 2019. V. 49. № 3. P. 421–430. https://doi.org/10.1017/S0033291718001034
- Evans J., Battersby S., Ogilvie A.D. et al. Association of short alleles of a VNTR of the serotonin transporter gene with anxiety symptoms in patients presenting after deliberate self-harm // Neuropharmacology. 1997. V. 36. № 4–5. P. 439–443. https://doi.org/10.1016/S0028-3908(97)00027-0
- Evans J., Reeves B., Platt H. et al. Impulsiveness, serotonin genes and repetition of deliberate self-harm (DSH) // Psychol. Med. 2000. V. 30. № 6. P. 1327–1334. https://doi.org/10.1017/S0033291799002822
- Joyce P.R., McKenzie J.M., Mulder R.T. et al. Genetic, developmental and personality correlates of self-mutilation in depressed patients // Aust. N. Z. J. Psychiatry. 2006. V. 40. № 3. P. 225–229. https://doi.org/10.1111/j.1440-1614.2006.01778.x
- Steiger H., Fichter M., Bruce K.R. et al. Molecular-genetic correlates of self-harming behaviors in eating-disordered women: Findings from a combined Canadian-German sample // Prog. Neuro-Psychopharmacology Biol. Psychiatry. 2011. V. 35. № 1. P. 102–106. https://doi.org/10.1016/j.pnpbp.2010.09.012
- Thaler L., Groleau P., Badawi G. et al. Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): Relationships to eating- and personality-related psychopathology // Prog. Neuro-Psychopharmacology Biol. Psychiatry. 2012. V. 39. № 1. P. 120–128. https://doi.org/10.1016/j.pnpbp.2012.05.019
- Dell’Osso L., Mandelli L., Carlini M. et al. Temperamental and genetic predictors of suicide attempt and self-mutilation // Neuropsychobiology. 2013. V. 68. № 4. P. 250–257. https://doi.org/10.1159/000356228
- Kolevzon A., Lim T., Schmeidler J. et al. Self-injury in autism spectrum disorder: An effect of serotonin transporter gene promoter variants // Psychiatry Res. 2014. V. 220. № 3. P. 987–990. https://doi.org/10.1016/j.psychres.2014.09.018
- Bresin K., Sima Finy M., Verona E. Childhood emotional environment and self-injurious behaviors: The moderating role of the BDNF Val66Met polymorphism // J. Affect. Disord. 2013. V. 150. № 2. P. 594–600. https://doi.org/10.1016/j.jad.2013.01.050
- Hankin B.L., Barrocas A.L., Young J.F. et al. 5‑HTTLPR × interpersonal stress interaction and nonsuicidal self-injury in general community sample of youth // Psychiatry Res. 2015. V. 225. № 3. P. 609–612. https://doi.org/10.1016/j.psychres.2014.11.037
- Gorodetsky E., Carli V., Sarchiapone M. et al. Predictors for self-directed aggression in Italian prisoners include externalizing behaviors, childhood trauma and the serotonin transporter gene polymorphism 5-HTTLPR // Genes, Brain Behav. 2016. V. 15. № 5. P. 465–473. https://doi.org/10.1111/gbb.12293
- Bernegger A., Kienesberger K., Carlberg L. et al. The impact of COMT and childhood maltreatment on suicidal behaviour in affective disorders // Sci. Rep. 2018. V. 8. № 1. P. 1–9. https://doi.org/10.1038/s41598-017-19040-z
- Gao Y., Xiong Y., Liu X., Wang H. The effects of childhood maltreatment on non-suicidal self-injury in male adolescents: The moderating roles of the monoamine oxidase a (maoa) gene and the catechol-o-methyltransferase (comt) gene // Int. J. Environ. Res. Public Health. 2021. V. 18. № 5. P. 1–13. https://doi.org/10.3390/ijerph18052598
- Martín-Blanco A., Ferrer M., Soler J. et al. Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder // J. Psychiatr. Res. 2014. V. 57. № 1. P. 34–40. https://doi.org/10.1016/j.jpsychires.2014.06.011
- Wang L., Zheng D., Liu L. et al. Relationship between SIRT1 gene and adolescent depressive disorder with nonsuicidal self-injury behavior: Based on gene methylation and mRNA expression // Medicine (Baltimore). 2021. V. 100. № 31. https://doi.org/10.1097/MD.0000000000026747
- Kullo I.J., Lewis C.M., Inouye M. et al. Polygenic scores in biomedical research // Nat. Rev. Genet. 2022. V. 23. № 9. P. 524–532. https://doi.org/10.1038/s41576-022-00470-z
- Hek K., Demirkan A., Lahti J. et al. A genome-wide association study of depressive symptoms // Biol. Psychiatry. 2013. V. 73. № 7. P. 667–678. https://doi.org/10.1016/j.biopsych.2012.09.033
- Maciejewski D.F., Renteria M.E., Abdellaoui A. et al. The association of genetic predisposition to depressive symptoms with non-suicidal and suicidal self-injuries // Behav. Genet. 2017. V. 47. № 1. P. 3–10. https://doi.org/10.1007/s10519-016-9809-z
- Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 // Nat. Genet. 2011. V. 43. № 10. P. 977–983. 10.1038/ng.943' target='_blank'>http://www.nature.com/articles/ng.943doi: 10.1038/ng.943
- Wilcox H.C., Fullerton J.M., Glowinski A.L. et al. Traumatic stress interacts with bipolar disorder genetic risk to increase risk for suicide attempts // J. Am. Acad. Child Adolesc. Psychiatry. 2017. V. 56. № 12. P. 1073–1080. https://doi.org/10.1016/j.jaac.2017.09.428
- Grove J., Ripke S., Als T.D. et al. Identification of common genetic risk variants for autism spectrum disorder // Nat. Genet. 2019. V. 51. № 3. P. 431–444. https://doi.org/10.1038/s41588-019-0344-8
- Warrier V., Baron-Cohen S. Childhood trauma, life-time self-harm, and suicidal behaviour and ideation are associated with polygenic scores for autism // Mol. Psychiatry. 2019. V. 26. № 5. P. 1670–1684. https://doi.org/10.1038/s41380-019-0550-x
- Hodgson K., Coleman J.R.I., Hagenaars S.P. et al. Cannabis use, depression and self-harm: phenotypic and genetic relationships // Addiction. 2020. V. 115. № 3. P. 482–492. https://doi.org/10.1111/add.14845
- Shen H., Gelaye B., Huang H. et al. Polygenic prediction and GWAS of depression, PTSD, and suicidal ideation/self-harm in a Peruvian cohort // Neuropsychopharmacology. 2020. V. 45. № 10. P. 1595–1602. https://doi.org/10.1038/s41386-020-0603-5
- Russell A.E., Ford T., Gunnell D. et al. Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian randomisation study // Brain. Behav. Immun. 2020. V. 89. P. 43–50. https://doi.org/10.1016/j.bbi.2020.05.065
- Lim K.X., Rijsdijk F., Hagenaars S.P. et al. Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study // PLoS Med. 2020. V. 17. № 1. https://doi.org/10.1371/journal.pmed.1003137
- Campos A.I., Verweij K.J.H., Statham D.J. et al. Genetic aetiology of self-harm ideation and behaviour// Sci. Rep. 2020. V. 10. № 1. P. 1–11. https://doi.org/10.1038/s41598-020-66737-9
- Manitt C., Eng C., Pokinko M. et al. DCC orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients // Transl. Psychiatry. 2013. V. 3. № 12. P. e338–e338. https://doi.org/10.1038/tp.2013.105
- Russell A.E., Hemani G., Jones H.J. et al. An exploration of the geneticepidemiology of non-suicidal self-harm and suicide attempt // BMC Psychiatry. 2021. V. 21. № 1. P. 207. https://doi.org/10.1186/s12888-021-03216-z
- Li C., Liang X., Cheng S. et al. A multi-environments-gene interaction study of anxiety, depression and self-harm in the UK Biobank cohort // J. Psychiatr. Res. 2022. V. 147. P. 59–66. https://doi.org/10.1016/j.jpsychires.2022.01.009