Mathematical Model Development for Schizophrenia Risk Prediction Based on Assessment of Polymorphic Alleles Carriage in 13 Genetic Loci Affecting Pterin Metabolism
- 作者: Zhilyaeva T.1,2, Bavrina A.1, Kasyanov E.2, Blagonravova A.1, Mazo G.2
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隶属关系:
- Privolzhsky Research Medical University
- Bekhterev National Research Medical Center Psychiatry and Neurology
- 期: 卷 59, 编号 5 (2023)
- 页面: 573-583
- 栏目: МАТЕМАТИЧЕСКИЕ МОДЕЛИ И МЕТОДЫ
- URL: https://journals.rcsi.science/0016-6758/article/view/134590
- DOI: https://doi.org/10.31857/S0016675823040112
- EDN: https://elibrary.ru/AYENHP
- ID: 134590
如何引用文章
详细
Real-time PCR was used to analyze the carriage of alleles in 13 genetic loci that affect pterin metabolism in 116 patients with schizophrenia and 62 healthy volunteers. To analyze the accuracy of predicting the risk of schizophrenia, we used the binary logistic regression method with the assessment of the contribution of all studied loci. Results: A mathematical model was developed that makes it possible to predict the risk of schizophrenia manifestation in a carrier of the combination of genotypes MTHFD1 1958CC/MTRR 66GG with a probability of 90.6%, MTHFD1 1958CC/MTRR66AG with a probability of 81.9%. The use of this model is expedient in routine psychiatric practice among individuals at high risk of schizophrenia manifestation after replication in other samples and obtaining a larger volume of observations.
作者简介
T. Zhilyaeva
Privolzhsky Research Medical University; Bekhterev National Research Medical Center Psychiatry and Neurology
编辑信件的主要联系方式.
Email: bizet@inbox.ru
Russia, 603005, Nizhny Novgorod; Russia, 192019, , St. Petersburg
A. Bavrina
Privolzhsky Research Medical University
Email: bizet@inbox.ru
Russia, 603005, Nizhny Novgorod
E. Kasyanov
Bekhterev National Research Medical Center Psychiatry and Neurology
Email: bizet@inbox.ru
Russia, 192019, , St. Petersburg
A. Blagonravova
Privolzhsky Research Medical University
Email: bizet@inbox.ru
Russia, 603005, Nizhny Novgorod
G. Mazo
Bekhterev National Research Medical Center Psychiatry and Neurology
Email: bizet@inbox.ru
Russia, 192019, , St. Petersburg
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