РОЛЬ ПРОСТРАНСТВЕННОЙ ОРГАНИЗАЦИИ ГЕНОМА В РЕГУЛЯЦИИ ТРАНСКРИПЦИИ

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Аннотация

В обзоре рассматривается роль пространственной организации генома в установлении коммуникации между энхансерами и промоторами. Особое внимание уделяется полногеномному анализу пространственных контактов между энхансерами и промоторами и идентификации белков, участвующих в поддержании этих контактов. Отдельно рассматривается роль экструзии хроматиновых петель котезиновыми комплексами в перемещении энхансеров к активируемым промоторам. В заключительной части статьи анализируются проблемы, требующие решения. В частности, рассматривается вопрос о том, насколько близко к промотору в физическом пространстве клеточного ядра должен располагаться энхансер для того, чтобы стало возможным установление коммуникации между этими регуляторными элементами.

Об авторах

С. В. Разин

Институт биологии гена Российской академии наук; Московский государственный университет им. М.В. Ломоносова

Email: sergey.v.razin@inbox.ru
Москва, Россия

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