Генетика и эпигенетика преждевременного полового созревания
- Авторы: Саженова Е.А.1, Васильев С.А.1, Рычкова Л.В.2, Храмова Е.Е.2, Лебедев И.Н.1
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Учреждения:
- Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук
- Научный центр проблем здоровья семьи и репродукции человека
- Выпуск: Том 59, № 12 (2023)
- Страницы: 1360-1371
- Раздел: ОБЗОРНЫЕ И ТЕОРЕТИЧЕСКИЕ СТАТЬИ
- URL: https://journals.rcsi.science/0016-6758/article/view/233633
- DOI: https://doi.org/10.31857/S001667582312010X
- EDN: https://elibrary.ru/QCJXMF
- ID: 233633
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Аннотация
Центральное преждевременное половое созревание (ППС) вызвано преждевременной реактивацией гипоталамо-гипофизарно-гонадной оси. В определении сроков полового созревания решающую роль играют генетические, эпигенетические и экологические факторы. В последние годы варианты в генах KISS1, KISS1R, MKRN3 и DLK1 были идентифицированы как наследственные причины ППС. Гены MKRN3 и DLK1 являются импринтированными, в связи с чем эпигенетические модификации, изменяющие экспрессию данных генов, также рассматриваются в качестве причины преждевременного полового созревания. При прогрессировании ППС эпигенетические факторы, такие как метилирование ДНК, посттрансляционные модификации гистонов и некодирующие РНК, могут опосредовать взаимосвязь между влиянием генетических вариантов и окружающей среды. ППС связано и с другими краткосрочными и долгосрочными неблагоприятными последствиями для здоровья. Это является основанием для исследований, направленных на понимание генетических и эпигенетических причин ППС. Цель настоящего обзора – обобщение данных литературы о молекулярно-генетических и эпигенетических механизмах формирования ППС.
Об авторах
Е. А. Саженова
Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук
Автор, ответственный за переписку.
Email: elena.sazhenova@medgenetics.ru
Россия, 634050, Томск
С. А. Васильев
Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук
Email: elena.sazhenova@medgenetics.ru
Россия, 634050, Томск
Л. В. Рычкова
Научный центр проблем здоровья семьи и репродукции человека
Email: elena.sazhenova@medgenetics.ru
Россия, 664003, Иркутск
Е. Е. Храмова
Научный центр проблем здоровья семьи и репродукции человека
Email: elena.sazhenova@medgenetics.ru
Россия, 664003, Иркутск
И. Н. Лебедев
Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук
Email: elena.sazhenova@medgenetics.ru
Россия, 634050, Томск
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