Изменение продолжительности жизни как интегральный ответ на иммунный статус организма и активность мобильных элементов

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Аннотация

Одной из ключевых задач при изучении молекулярно-генетических основ многих патологий является поиск триггеров, влияние на которые могло бы положительно сказаться на частоте возникновения зависимых от возраста заболеваний и в целом темпах старения. Возможной причиной зависимой от возраста деградации функций организма, индуцирующей старение, является иммуносенесцентность. Известно, что наблюдаемое с возрастом повышение активности мобильных элементов может не только влиять на уровень стабильности генома, но и играть ключевую роль в формировании иммунного ответа. В то же время давно доказана ключевая роль нервной системы в контроле продолжительности жизни, а недавно показано, что компоненты аппарата, регулирующего активность мобильных элементов, функционируют в нервной системе, и их работа влияет на развитие нейродегенеративных заболеваний. В мини-обзоре представлены факты, указывающие на комплексную регуляцию старения со стороны нервной и иммунной систем при участии систем контроля активности мобильных элементов и предложена гипотетическая схема их совместного влияния на продолжительность жизни.

Об авторах

М. В. Тростников

Национальный исследовательский центр “Курчатовский институт”; Сколковский институт науки и технологий

Автор, ответственный за переписку.
Email: mikhail.trostnikov@gmail.com
Россия, 123182, Москва; Россия, 121205, Московская область, Сколково

Д. Р. Малышев

Национальный исследовательский центр “Курчатовский институт”

Email: mikhail.trostnikov@gmail.com
Россия, 123182, Москва

Е. Г. Пасюкова

Национальный исследовательский центр “Курчатовский институт”

Email: mikhail.trostnikov@gmail.com
Россия, 123182, Москва

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