Polymorphism of the MAOA Gene (rs1137070) and Internet Addiction in Adolescents
- Autores: Kopylova K.1, Marchenko I.1, Shubina M.1, Gorbacheva N.1, Novitckii I.1, Smolnikova M.1
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Afiliações:
- Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarski Scientific Center Siberian Branch of the Russian Academy of Scienses”
- Edição: Volume 59, Nº 10 (2023)
- Páginas: 1191-1198
- Seção: ГЕНЕТИКА ЧЕЛОВЕКА
- URL: https://journals.rcsi.science/0016-6758/article/view/140395
- DOI: https://doi.org/10.31857/S0016675823100065
- EDN: https://elibrary.ru/UCMSOE
- ID: 140395
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Resumo
Monoamine oxidase A (MAOA) catalyzes the degradation of norepinephrine, dopamine, and serotonin, i.e. neurotransmitters involved in the pathogenesis of pathological addictions, including internet addiction (IA). Gene MAOA has been actively studied in terms of genetic predisposition to the development of aggressive behavior potentially involved in the formation of IA. The study included 602 adolescents (9–18 years old, mean age = 14.6, SD 1.7) from the Angara-Yenisei macroregion (Russians n = 329, Tuvans n = 158, Khakasses n = 158). The type of IA was assessed according to the Chen scale (Chen Internet Addiction Scale, CIAS), gene polymorphism was detected using real-time PCR. The distribution of the TT genotype of MAOA rs1137070 polymorphism associated with low activity of the monoamine oxidase A enzyme and aggressive behavior affected by IA, was found to be significantly higher in Tuvan adolescents compared with Russians (31.1/21.2% p = = 0.02). Pathological internet addiction (more than 65 points by Chen scale) often observed among Khakass adolescents compared to Russian (26.4/15.5%, p = 0.03). Thus, the allelic variant T of MAOA rs1137070 polymorphism appears to be potential marker for dependent and aggressive behavior to form, Asian representatives being more susceptible to the development of pathological addictions than Caucasian populations.
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Sobre autores
K. Kopylova
Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarski ScientificCenter Siberian Branch of the Russian Academy of Scienses”
Email: smarinv@yandex.ru
Russia, 660022, Krasnoyarsk
I. Marchenko
Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarski ScientificCenter Siberian Branch of the Russian Academy of Scienses”
Email: smarinv@yandex.ru
Russia, 660022, Krasnoyarsk
M. Shubina
Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarski ScientificCenter Siberian Branch of the Russian Academy of Scienses”
Email: smarinv@yandex.ru
Russia, 660022, Krasnoyarsk
N. Gorbacheva
Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarski ScientificCenter Siberian Branch of the Russian Academy of Scienses”
Email: smarinv@yandex.ru
Russia, 660022, Krasnoyarsk
I. Novitckii
Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarski ScientificCenter Siberian Branch of the Russian Academy of Scienses”
Email: smarinv@yandex.ru
Russia, 660022, Krasnoyarsk
M. Smolnikova
Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarski ScientificCenter Siberian Branch of the Russian Academy of Scienses”
Autor responsável pela correspondência
Email: smarinv@yandex.ru
Russia, 660022, Krasnoyarsk
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