The Effect of the aPKC Gene Encoding Atypical Protein Kinase C on the Lifespan of Drosophila melanogaster Depends on the Expression Level of Protein Kinase GSK3
- Autores: Trostnikov M.1, Veselkina E.1, Andreev Y.1, Khryachkova A.1, Roshina N.1,2, Pasyukova E.1
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Afiliações:
- Institute of Molecular Genetics of the National Research Centre “Kurchatov Institute”
- Vavilov Institute of General Genetics, Russian Academy of Sciences
- Edição: Volume 59, Nº 1 (2023)
- Páginas: 26-38
- Seção: ОБЩАЯ ГЕНЕТИКА
- URL: https://journals.rcsi.science/0016-6758/article/view/134499
- DOI: https://doi.org/10.31857/S0016675823010125
- EDN: https://elibrary.ru/CNOZBD
- ID: 134499
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Resumo
Drosophila melanogaster shaggy and aPKC genes encode highly conserved GSK3 (Glycogen Syntase Kinase 3) and aPKC (Protein Kinase C) proteinkinases that play key roles in many cellular processes. We previously demonstrated that changes in shaggy expression in neurons affect lifespan. In this article we show that changing the expression of the aPKC gene in neurons also affects lifespan. Changing the expression of the two protein kinases in all male or female neurons and in male motoneurons led to changes in lifespan, indicating that aPKC has no effect on GSK3 and GSK3 has a possible inhibitory effect on aPKC. At the same time, changes in the expression of two protein kinases in female motoneurons led to changes in lifespan, indicating the existence of a still unclear mechanism of interaction between these proteins. The elucidation of the mechanisms of interaction between aPKC, GSK3 and their other partners will deepen and expand our understanding of the causes of longevity and the ways to extend life.
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Sobre autores
M. Trostnikov
Institute of Molecular Genetics of the National Research Centre “Kurchatov Institute”
Autor responsável pela correspondência
Email: mikhail.trostnikov@gmail.com
Russia, 123182, Moscow
E. Veselkina
Institute of Molecular Genetics of the National Research Centre “Kurchatov Institute”
Email: mikhail.trostnikov@gmail.com
Russia, 123182, Moscow
Y. Andreev
Institute of Molecular Genetics of the National Research Centre “Kurchatov Institute”
Email: mikhail.trostnikov@gmail.com
Russia, 123182, Moscow
A. Khryachkova
Institute of Molecular Genetics of the National Research Centre “Kurchatov Institute”
Email: mikhail.trostnikov@gmail.com
Russia, 123182, Moscow
N. Roshina
Institute of Molecular Genetics of the National Research Centre “Kurchatov Institute”; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: mikhail.trostnikov@gmail.com
Russia, 123182, Moscow; Russia, 119991, Moscow
E. Pasyukova
Institute of Molecular Genetics of the National Research Centre “Kurchatov Institute”
Email: mikhail.trostnikov@gmail.com
Russia, 123182, Moscow
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