Synthesis and physicochemical properties of antianemic iron and calcium complexes with sodium polygalacturonate

Abstract

New stable water-soluble metal complexes of citrus pectin (sodium polygalacturonate, PG-Na) with biogenic microelements (Ca and Fe) that we synthesized were characterized by infrared spectroscopy, dynamic light scattering, and atomic force microscopy. The temperature dependence of the mass of PG-Na, PG-NaFe, and PG-NaFeCa samples was studied by simultaneous thermal analysis. Water was found to be the major component of the gas phase in the first stage of mass loss of PG-NaFe and PG-NaFeCa, while the second stage involves decarboxylation and decomposition. The stimulating action of PG-NaFe and PG-NaFeCa on hematopoiesis in outbred rats during growing period, manifested as more than 10% increase in the hemoglobin concentration, was demonstrated.