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Vol 485, No 1 (2019)
- Year: 2019
- Articles: 5
- URL: https://journals.rcsi.science/0012-5008/issue/view/9313
Chemistry
Synthesis and Properties of New 2,3,5,6-Tetraaminopyridine-Based Polyheteroarylenes
Abstract
Two new polyheteroarylenes (polydiimidazopyridines) based on 2,3,5,6-tetraaminopyridine and aromatic dicarboxylic acids were synthesized and characterized. The polymers show high viscosity properties and exceptional thermooxidative stability. Polydiimidazopyridine containing a phosphoric acid group possesses excellent film-forming properties and can be processed to proton-conducting membranes that have record high proton conductivity in the temperature range of 20–200°C after doping with orthophosphoric acid.
83-86
Synthesis of Isotopically Modified Derivatives of Dopamine, Serotonin, and Doxorubicin with Boc-Pro and Boc-[2H]Pro
Abstract
Boc-Pro-Dox, Boc-Pro-DOPA, Boc-Pro-Srt, and Pro-Dox, Pro-DOPA, Pro-Srt, as well as Boc-[2Н]Pro-Dox, Boc-[2Н]Pro-DOPA, Boc-[2Н]Pro-Srt, and [2Н]Pro-Dox, [2Н]Pro-DOPA, [2Н]Pro-Srt have been synthesized for the first time. Boc-[2Н]Pro is the most promising reagent for the preparation of deuterated compounds. The hydrogenation of Boc-ΔPro in ethyl acetate on palladium catalyst has allowed the introduction of deuterium by a factor of 1.6–1.65 larger than by the hydrogenation of unsaturated proline bound to serotonin and by a factor of three larger than by the hydrogenation of unsaturated proline bound to dopamine. Due to doxorubicin instability under conditions of unsaturated proline hydrogenation, its condensation with Boc-[2Н]Pro is the sole possibility to prepare Boc-[2Н]Pro-Dox. The content of isotopomers in the deuterated products has been determined by mass spectrometry.
87-90
Water-Soluble Metal–Polymer Gallium Complexes with N-Vinylpyrrolidone–N-Vinylformamide–N-Vinyliminodiacetic Acid Terpolymer
Abstract
A terpolymer with a molecular weight of 45 kDa containing 7 mol % of vinylamine units, 80 mol % of vinylpyrrolidone, and 3 mol % of vinyliminodiacetic acid units has been synthesized. Its complexation with Ga3+ ion has been studied by HPLC. The resulting metal–polymer complex has been characterized by exclusion chromatography and spectral (IR, 1H NMR) data. The complex has a monomolecular structure where the metal ion acts as an anchor fragment between vinyliminodiacetic acid units and is stable in the reaction of interligand exchange with histidine.
91-94
New 4,5-Diaza-9,9'-spirobifluorene Derivative—A Promising Electron Acceptor for Nonfullerene Polymer Solar Cells
Abstract
A new 4,5-diaza-9,9'-spirobifluorene derivative 8 containing two electron-withdrawing perylenediimide moieties has been synthesized. The compound has been characterized by NMR, elemental analysis, UV spectroscopy, and cyclic voltammetry. The HOMO/LUMO energies of compound 8 are –5.81 eV/–3.89 eV; the \(E_{{\text{g}}}^{{{\text{opt}}}}\) = 1.75 eV, and \(E_{{\text{g}}}^{{{\text{ec}}}}\) = 1.92 eV. Low HOMO/LUMO energies and strong absorption in the visible range of the UV spectrum point to the possibility to use compound 8 as a promising electron acceptor for nonfullerene polymer solar cells.
95-99
Chemical Technology
Bone Cements Based on Magnesium-Substituted Calcium Sulfates
Abstract
Calcium sulfate-based powders with magnesium substituting for calcium cations in amounts of 10, 20, and 40 mol % were synthesized by the mechanochemical method. The phase composition of the products, the solubility, and the compressive strength of the obtained cement materials mixed with water were studied. It was shown that the solubility in the physiological saline increases, while the strength of set cements decreases with increasing degree of substitution. The materials are applicable for bone grafting in surgery, for fabrication of composite biomaterials, and as carriers for targeted drug delivery in the human body.
100-103