Copper-Containing Nanosystems Based on Macromolecular Hydrophilic Stabilizers

Abstract

An original method for the synthesis of copper-containing nanosystems for biomedical applications using hydrazine hydrate as a reducing agent was developed. The process involves intermediate formation of the [Cu(NH₃)₄]²⁺ complex ion, which ensures the formation of Cu⁰ nanoparticles without oxide impurity. The 2-deoxy-2-methacrylamido-D-glucose copolymer with 2-(dimethylamino)ethyl methacrylate or bovine serum albumin was used as a macromolecular hydrophilic stabilizer. The spectral and structure-morphological characteristics of the nanosystems were studied. This stabilization resulted in an almost unimodal distribution of zerovalent copper nanoparticles in aqueous solutions due to their rather good shielding by macromolecules.