The Reactivity of 3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate and Reference Drugs in Model NO-Generating Systems

Abstract

The ability of 3-hydroxy-6-methyl-2-ethylpyridine 2-nitroxysuccinate (I) to generate nitrite ions (\({\text{NO}}_{2}^{ - }\)) and nitrogen monoxide (NO) in model systems with cysteine (Cys) and deoxyhemoglobin (Hb) has been studied. Compound I has been found to release \({\text{NO}}_{2}^{ - }\) and NO more efficiently than Nicorandil. The accumulation rate of \({\text{NO}}_{2}^{ - }\) in the system of Cys with I is by a factor of 1.5 higher than that with Nitroglycerin. It has been shown that, in contrast to Nitroglycerin, compound I is not reduced by Hb.