Molecular Targets of Natriuretic Action of Prolactin in the Rat Model of Cholestasis of Pregnancy
- 作者: Abramicheva P.1, Kostenko Y.1, Balakina T.1, Smirnova O.1
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隶属关系:
- M. V. Lomonosov Moscow State University
- 期: 卷 168, 编号 2 (2019)
- 页面: 219-223
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242371
- DOI: https://doi.org/10.1007/s10517-019-04678-8
- ID: 242371
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详细
We analyzed the expression of molecular targets of natriuretic action of prolactin in different layers of the kidney in the rat model of cholestasis of pregnancy. Sodium bicarbonate cotransporter NBCe1 was most sensitive to the conditions of cholestasis and cholestasis of pregnancy: the expression NBCe1 mRNA and protein in the renal outer medulla decreased in comparison with the normal. All forms of cholestasis affected the mRNA expression of sodium-potassium chloride co-transporter NCC, α-subunit of the ENaCα epithelial sodium channel, and Nedd4-2 ubiquitin ligase in different layers of the kidney. The obtained data suggest that prolactin provides fine tuning of various sodium transporters in different parts of the nephron under pathological conditions.
作者简介
P. Abramicheva
M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: abramicheva.polina@gmail.com
俄罗斯联邦, Moscow
Yu. Kostenko
M. V. Lomonosov Moscow State University
Email: abramicheva.polina@gmail.com
俄罗斯联邦, Moscow
T. Balakina
M. V. Lomonosov Moscow State University
Email: abramicheva.polina@gmail.com
俄罗斯联邦, Moscow
O. Smirnova
M. V. Lomonosov Moscow State University
Email: abramicheva.polina@gmail.com
俄罗斯联邦, Moscow
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