Effects of Blockage of Peripheral Choline, Serotonin, and Dopamine Receptors on Heart Rhythm Variability in Rats under Conditions of Stimulation of Neurotransmitter Systems
- 作者: Kur’yanova E.1, Stupin V.1, Tryasuchev A.1, Teplyi D.1
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隶属关系:
- Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
- 期: 卷 168, 编号 2 (2019)
- 页面: 193-198
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242361
- DOI: https://doi.org/10.1007/s10517-019-04673-z
- ID: 242361
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详细
Stimulation of the serotoninergic system (5-hydroxytryptophan, 50 mg/kg; fluoxetine, 3 mg/kg) induced a significant increase in HR and a reduction in the amplitude of all waves of the heart rhythm variability. Stimulation of the dopaminergic system (L-DOPA and amantadine, 20 mg/kg each) resulted in a moderate increase in HR and amplitudes of low-frequency (LF) and very-low-frequency (VLF) waves of the heart rhythm variability. Successive blockade of nicotinic (hexamethonium, 7 mg/kg) and muscarinic cholinergic receptors (atropine, 1 mg/kg) leads to a significant decrease in the variability of cardiointervals (almost to complete levelling) both under control conditions and after stimulation of the neurotransmitter systems. Serotonin receptor blockade (promethazine, 2 mg/kg) did not affect HR, but reduced the amplitude of LF- and VLF-waves. Under conditions of serotoninergic system stimulation, the blockade of serotonin receptors was followed by a significant HR acceleration without changes in heart rhythm variability; blockade of dopamine receptors (sulpiride, 1 mg/kg) induced HR acceleration and increase in the amplitude of LF- and VLF-waves; blockade of dopamine receptors under conditions of dopamine system stimulation was followed by a significant increase in HR and a decrease in the amplitude of all waves of the heart rhythm variability. It can be hypothesized that serotonin- and dopaminergic systems affect the heart rhythm via cardiomyocyte receptors and via modulation of activity of the adrenergic and cholinergic systems. The effects of serotonin- and dopaminergic systems can be considered as synergic in the CNS, and antagonistic at the periphery.
作者简介
E. Kur’yanova
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
编辑信件的主要联系方式.
Email: fyzevk@rambler.ru
俄罗斯联邦, Astrakhan
V. Stupin
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Email: fyzevk@rambler.ru
俄罗斯联邦, Astrakhan
A. Tryasuchev
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Email: fyzevk@rambler.ru
俄罗斯联邦, Astrakhan
D. Teplyi
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Email: fyzevk@rambler.ru
俄罗斯联邦, Astrakhan