Effects of Blockage of Peripheral Choline, Serotonin, and Dopamine Receptors on Heart Rhythm Variability in Rats under Conditions of Stimulation of Neurotransmitter Systems
- Авторлар: Kur’yanova E.1, Stupin V.1, Tryasuchev A.1, Teplyi D.1
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Мекемелер:
- Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
- Шығарылым: Том 168, № 2 (2019)
- Беттер: 193-198
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242361
- DOI: https://doi.org/10.1007/s10517-019-04673-z
- ID: 242361
Дәйексөз келтіру
Аннотация
Stimulation of the serotoninergic system (5-hydroxytryptophan, 50 mg/kg; fluoxetine, 3 mg/kg) induced a significant increase in HR and a reduction in the amplitude of all waves of the heart rhythm variability. Stimulation of the dopaminergic system (L-DOPA and amantadine, 20 mg/kg each) resulted in a moderate increase in HR and amplitudes of low-frequency (LF) and very-low-frequency (VLF) waves of the heart rhythm variability. Successive blockade of nicotinic (hexamethonium, 7 mg/kg) and muscarinic cholinergic receptors (atropine, 1 mg/kg) leads to a significant decrease in the variability of cardiointervals (almost to complete levelling) both under control conditions and after stimulation of the neurotransmitter systems. Serotonin receptor blockade (promethazine, 2 mg/kg) did not affect HR, but reduced the amplitude of LF- and VLF-waves. Under conditions of serotoninergic system stimulation, the blockade of serotonin receptors was followed by a significant HR acceleration without changes in heart rhythm variability; blockade of dopamine receptors (sulpiride, 1 mg/kg) induced HR acceleration and increase in the amplitude of LF- and VLF-waves; blockade of dopamine receptors under conditions of dopamine system stimulation was followed by a significant increase in HR and a decrease in the amplitude of all waves of the heart rhythm variability. It can be hypothesized that serotonin- and dopaminergic systems affect the heart rhythm via cardiomyocyte receptors and via modulation of activity of the adrenergic and cholinergic systems. The effects of serotonin- and dopaminergic systems can be considered as synergic in the CNS, and antagonistic at the periphery.
Авторлар туралы
E. Kur’yanova
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Хат алмасуға жауапты Автор.
Email: fyzevk@rambler.ru
Ресей, Astrakhan
V. Stupin
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Email: fyzevk@rambler.ru
Ресей, Astrakhan
A. Tryasuchev
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Email: fyzevk@rambler.ru
Ресей, Astrakhan
D. Teplyi
Department of Physiology, Morphology, Genetics, and Biomedicine, Astrakhan State University
Email: fyzevk@rambler.ru
Ресей, Astrakhan
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