Analysis of the Effect of IL-1β on Blood—Brain Barrier Permeability in M6 Glioma Mouse Model Using Intravital Microscopy
- 作者: Melnikov P.1, Valikhov M.1, Kuznetsov I.1, Grinenko N.1, Sukhinich K.2, Simbirtsev A.3, Kekelidze Z.1, Chekhonin V.1
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隶属关系:
- Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation
- N. K. Koltsov Institute of Developmental Biology
- State Research Institute of Highly Pure Biopreparations
- 期: 卷 168, 编号 1 (2019)
- 页面: 118-124
- 栏目: Cell Technologies in Biology and Medicine
- URL: https://journals.rcsi.science/0007-4888/article/view/242277
- DOI: https://doi.org/10.1007/s10517-019-04661-3
- ID: 242277
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详细
We studied the effect of IL-1β on the permeability of brain capillaries in healthy mice. Intravital microscopy demonstrated that parenteral administration of IL-1β was followed by an increase in vascular permeability ensuring passage of free Alexa488 fluorescent label through the capillary walls, but not sufficient for penetration of liposomes. In addition, experiments on mice with intracranial M6 glioma showed penetration of liposomes through the walls of tumor capillaries after parenteral administration of IL-1β in a concentration of 2 μg/ml. Thus, the use of proinflammatory cytokine IL-1β in the therapy of brain tumors can significantly increase the therapeutic efficacy of drug delivery systems, in particular, for drugs poorly crossing the blood—brain barrier.
作者简介
P. Melnikov
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: marat.valikhov@gmail.com
俄罗斯联邦, Moscow
M. Valikhov
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: marat.valikhov@gmail.com
俄罗斯联邦, Moscow
I. Kuznetsov
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: marat.valikhov@gmail.com
俄罗斯联邦, Moscow
N. Grinenko
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: marat.valikhov@gmail.com
俄罗斯联邦, Moscow
K. Sukhinich
N. K. Koltsov Institute of Developmental Biology
Email: marat.valikhov@gmail.com
俄罗斯联邦, Moscow
A. Simbirtsev
State Research Institute of Highly Pure Biopreparations
Email: marat.valikhov@gmail.com
俄罗斯联邦, St. Petersburg
Z. Kekelidze
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: marat.valikhov@gmail.com
俄罗斯联邦, Moscow
V. Chekhonin
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: marat.valikhov@gmail.com
俄罗斯联邦, Moscow