Effects of Melatonin on the Body Composition, Physical Performance, and Blood Erythrocyte Indexes of C57Bl/6J Mice Exposed to Continuous Illumination
- 作者: Michurina S.1, Ishchenko I.1, Korolev M.1, Letyagin A.1,2, Rachkovskaya L.1, Khotskina A.2, Khotskin N.2, Maslennikova S.2, Zavjalov E.2
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隶属关系:
- Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- 期: 卷 168, 编号 1 (2019)
- 页面: 28-32
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242175
- DOI: https://doi.org/10.1007/s10517-019-04638-2
- ID: 242175
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详细
Male C57Bl/6J mice were exposed to daily 24-h illumination over 14 days and daily intragastrically received melatonin (1 mg/kg) or water (placebo). Controls were kept under standard day/night (14/10 h) conditions. Melatonin prevented the development of anemia in mice exposed to continuous illumination, which was proven by higher blood hemoglobin levels by the end of the experiment in melatonin-treated animals in comparison with the placebo group. Studies by the low-field NMR spectrometry detected lower lean body mass, total body water, and especially, fat content (by ~13%) in animals receiving placebo. Melatonin treatment led to an increase in the lean body mass and total body water on day 7 (in comparison with the placebo group) without affecting fat mass. On day 14 of continuous illumination, lean body mass increased in comparison with the corresponding parameter in the control and placebo groups. Melatonin had no effect on the physical endurance of mice exposed to continuous illumination (assessed by the grid hanging test).
作者简介
S. Michurina
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
I. Ishchenko
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
M. Korolev
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
A. Letyagin
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
L. Rachkovskaya
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
A. Khotskina
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
N. Khotskin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
S. Maslennikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
E. Zavjalov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk